341-27-5

Basic information

• Product Name: 3-FLUORO-2-HYDROXYBENZOIC ACID
• Synonyms: RARECHEM AL BE 0031;3-FLUOROSALICYLIC ACID;3-FLUORO-2-HYDROXYBENZOIC ACID;3-FLUORO-2-HYDROXYBENZOIC ACID(3-FLUOROSALICYLIC ACID);2-Hydroxy-3-fluorobenzoic acid;NSC 109100;3-Fluorosalicylic acid, 2-Carboxy-6-fluorophenol
• CAS NO: 341-27-5
• Molecular Formula: C₇H₅FO₃
• Molecular Weight: 156.11
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Aryl;Carboxy;Intermediate;Building Blocks;Fluorine series
• Mol File: 341-27-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 142 °C
• Boiling Point: 271℃
• Flash Point: 117℃
• Appearance: off-white solid
• Density: 1.492
• Vapor Pressure: 0.00336mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 2.45±0.10(Predicted)
• CAS DataBase Reference: 3-FLUORO-2-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-2-HYDROXYBENZOIC ACID(341-27-5)
• EPA Substance Registry System: 3-FLUORO-2-HYDROXYBENZOIC ACID(341-27-5)

Safety Data

• Hazard Codes: C,Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 341-27-5(Hazardous Substances Data)

Usage

General Description

3-Fluoro-2-hydroxybenzoic acid is a chemical compound with the molecular formula C7H5FO3. 3-Fluoro-2-hydroxybenzoic acid is a derivative of benzoic acid, with a hydroxyl group and a fluorine atom attached to the benzene ring. It is commonly used in organic synthesis and pharmaceutical research as an intermediate in the production of various drugs and bioactive compounds. 3-Fluoro-2-hydroxybenzoic acid has potential applications in the pharmaceutical industry due to its interesting chemical structure and properties, making it an important compound for further study and development.

InChI:InChI=1/C7H5FO3/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,9H,(H,10,11)

Upstream product

• 251300-28-4 5-bromo-3-fluoro-2-hydroxybenzaldehyde 
• 2105-94-4 4-bromo-2-fluorophenol 
• 117570-31-7 fluoro-1 methoxymethylenoxy-2 benzene 
• 367-12-4 2-fluorophenol 
• 854914-89-9 3-fluoro-2-hydroxy-thiobenzoic acid S-methyl ester 
• 124-38-9 carbon dioxide 
• 15719-64-9 methylammonium carbonate 
• 251300-29-5 5-bromo-3-fluoro-2-hydroxybenzoic acid 
• 394-50-3 3-fluorosalicylaldehyde 

Downstream Products

• 1106305-59-2 benzyl 3-fluoro-2-hydroxybenzoate 
• 938177-13-0 5-bromo-2-{3-fluoro-2-[(phenylmethyl)oxy]phenyl}-6-methyl-3-(2-phenylethyl)-4(3H)-pyrimidinone 
• 938180-21-3 2-{3-fluoro-2-[(phenylmethyl)oxy]phenyl}-6-methyl-3-(2-phenylethyl)-4(3H)-pyrimidinone 
• 148872-79-1 3-fluoro-2-[(phenylmethyl)oxy]benzoic acid 
• 938180-01-9 2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone 
• 2387-23-7 1,3-Dicyclohexylurea 

Relevant articles and documents

A highly efficient strategy for the synthesis of 3-substituted salicylic acids by either directed ortho-lithiation or halogen-metal exchange of substituted mom protected phenols followed by carboxylation

A highly efficient synthesis of various 3-substituted salicylic acids is described starting from inexpensive starting materials and requiring no special apparatus.

An improved method for the synthesis of 3-fluorosalicylic acid with application to the synthesis of 3-(Trifluoromethyl)salicylic acid

An improved method for the synthesis of 3-fluorosalicylic acid is described. A positional protective group strategy allows formylation selectively at the ortho position of 4-bromo-2-fluorophenol. Oxidation of the resulting salicylaldehyde to the salicylic acid, followed by debromination, affords 3-fluorosalicylic acid. The method has also been applied to the synthesis of 3-(trifluoromethyl)salicylic acid.