(S)-(-)-6-(N-benzyloxycarbonylprolylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester

Base Information

Chemical Name:(S)-(-)-6-(N-benzyloxycarbonylprolylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester
CAS No.:221319-75-1
Molecular Formula:C₂₄H₃₃N₃O₇
Molecular Weight:475.542
Hs Code.:

Synonyms:(S)-(-)-6-(N-benzyloxycarbonylprolylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester

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Chemical Property of (S)-(-)-6-(N-benzyloxycarbonylprolylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester

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Technology Process of (S)-(-)-6-(N-benzyloxycarbonylprolylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester

There total 3 articles about (S)-(-)-6-(N-benzyloxycarbonylprolylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 221319-68-2
(S)-(-)-6-amino-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 221319-75-1
(S)-(-)-6-(N-benzyloxycarbonylprolylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; 1.) -10 deg C, 5 min; 2.) RT, 30 min;
DOI:10.3987/com-98-8403

Reference yield:

: 221319-62-6
(S)-(+)-N,N-dibenzylamino-2,2-dimethyl-1,3-oxazepan-4-one

: 221319-75-1
(S)-(-)-6-(N-benzyloxycarbonylprolylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / 1.) NaH / tetrahydrofuran / 1.) 0 deg C, 1 h; 2.) up to 5 deg C during 4 h

2: 88 percent / H₂ / 10 percent Pd/C / methanol / 24 h / 750.06 Torr / Ambient temperature

3: 76 percent / N-methylmorpholine, ClCO₂-iBu / tetrahydrofuran / 1.) -10 deg C, 5 min; 2.) RT, 30 min

With 4-methyl-morpholine; hydrogen; sodium hydride; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.3987/com-98-8403

Reference yield:

: 221319-66-0
(S)-(+)-6-(N,N-dibenzylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester

: 221319-75-1
(S)-(-)-6-(N-benzyloxycarbonylprolylamino)-2,2-dimethyl-1,3-oxazepan-4-on-3-ylacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / H₂ / 10 percent Pd/C / methanol / 24 h / 750.06 Torr / Ambient temperature

2: 76 percent / N-methylmorpholine, ClCO₂-iBu / tetrahydrofuran / 1.) -10 deg C, 5 min; 2.) RT, 30 min

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.3987/com-98-8403