2-[1-(3-chloro-3'-methanesulfonyl-biphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-4,5-dihydrooxazole

Base Information

Chemical Name:2-[1-(3-chloro-3'-methanesulfonyl-biphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-4,5-dihydrooxazole
CAS No.:1033575-79-9
Molecular Formula:C₂₅H₁₈Cl₃N₃O₃S
Molecular Weight:546.861
Hs Code.:

Synonyms:2-[1-(3-chloro-3'-methanesulfonyl-biphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-4,5-dihydrooxazole

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Chemical Property of 2-[1-(3-chloro-3'-methanesulfonyl-biphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-4,5-dihydrooxazole

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Technology Process of 2-[1-(3-chloro-3'-methanesulfonyl-biphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-4,5-dihydrooxazole

There total 8 articles about 2-[1-(3-chloro-3'-methanesulfonyl-biphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 918349-06-1
1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazole-4-carboxylic acid (2-hydroxyethyl)amide

: 1033575-79-9
2-[1-(3-chloro-3'-methanesulfonyl-biphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-4,5-dihydrooxazole

Guidance literature:: With PPA; at 130 ℃; for 2.5h;

Reference yield:

: 1033586-53-6
N-(4-bromo-2-chlorophenyl)-2,6-dichlorobenzamidine

: 1033575-79-9
2-[1-(3-chloro-3'-methanesulfonyl-biphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / ethanol / 2.5 h / Heating / reflux

1.2: 1 h / Heating / reflux

2.1: water; potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 2.5 h / 80 °C

3.1: sodium hydroxide; water / methanol / 2 h / 50 °C

4.1: hydrogenchloride / methanol; water; ethyl acetate

5.1: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 1.5 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine / chloroform / 1 h / 50 °C

7.1: PPA / 2.5 h / 130 °C

With hydrogenchloride; sodium hydroxide; PPA; oxalyl dichloride; water; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N,N-dimethyl-formamide; In methanol; 1,2-dimethoxyethane; ethanol; chloroform; water; ethyl acetate; 2.1: Suzuki Coupling;

Reference yield:

: 918350-19-3
1-(4-bromo-2-chlorophenyl)-2-(2,6-dichlorophenyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 1033575-79-9
2-[1-(3-chloro-3'-methanesulfonyl-biphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 6 steps

1: water; potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 2.5 h / 80 °C

2: sodium hydroxide; water / methanol / 2 h / 50 °C

3: hydrogenchloride / methanol; water; ethyl acetate

4: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 1.5 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / chloroform / 1 h / 50 °C

6: PPA / 2.5 h / 130 °C

With hydrogenchloride; sodium hydroxide; PPA; oxalyl dichloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N,N-dimethyl-formamide; In methanol; 1,2-dimethoxyethane; chloroform; water; ethyl acetate; 1: Suzuki Coupling;