2-(7-benzyloxy-4-methyl-1-phenylsulfanyl-hept-3-enyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone

Base Information

• Chemical Name: 2-(7-benzyloxy-4-methyl-1-phenylsulfanyl-hept-3-enyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone
• CAS No.: 903550-07-2
• Molecular Formula: C₃₄H₅₀O₃SSi
• Molecular Weight: 566.921
• Mol file: 903550-07-2.mol

Synonyms:2-(7-benzyloxy-4-methyl-1-phenylsulfanyl-hept-3-enyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone

Chemical Property of 2-(7-benzyloxy-4-methyl-1-phenylsulfanyl-hept-3-enyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(7-benzyloxy-4-methyl-1-phenylsulfanyl-hept-3-enyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone

There total 7 articles about 2-(7-benzyloxy-4-methyl-1-phenylsulfanyl-hept-3-enyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone (902140-86-7) + C21H25ClOS (902140-94-7) → 2-(7-benzyloxy-4-methyl-1-phenylsulfanyl-hept-3-enyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone (903550-07-2)

Guidance literature:

3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone; With potassium hydride; In tetrahydrofuran; at 20 ℃;

With zinc(II) chloride; In tetrahydrofuran; at -15 ℃;

C₂₁H₂₅ClOS; In tetrahydrofuran; at -80 - 20 ℃; for 15h;

DOI:10.1055/s-2006-939064

Reference yield:

Methanesulfonic acid (E)-7-benzyloxy-4-methyl-hept-3-enyl ester → 2-(7-benzyloxy-4-methyl-1-phenylsulfanyl-hept-3-enyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone (903550-07-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butoxide / dimethylsulfoxide / 1 h / 20 °C

2.1: N-chlorosuccinimide / CCl₄ / 12 h / 20 °C

3.1: KH / tetrahydrofuran / 20 °C

3.2: ZnCl₂ / tetrahydrofuran / -15 °C

3.3: 35 percent / tetrahydrofuran / 15 h / -80 - 20 °C

With N-chloro-succinimide; potassium tert-butylate; potassium hydride; In tetrahydrofuran; tetrachloromethane; dimethyl sulfoxide;

DOI:10.1055/s-2006-939064

Reference yield:

C21H26OS (902141-05-3) → 2-(7-benzyloxy-4-methyl-1-phenylsulfanyl-hept-3-enyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone (903550-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-chlorosuccinimide / CCl₄ / 12 h / 20 °C

2.1: KH / tetrahydrofuran / 20 °C

2.2: ZnCl₂ / tetrahydrofuran / -15 °C

2.3: 35 percent / tetrahydrofuran / 15 h / -80 - 20 °C

With N-chloro-succinimide; potassium hydride; In tetrahydrofuran; tetrachloromethane;

DOI:10.1055/s-2006-939064

upstream raw materials:

3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methyl-cyclopentanone

C₂₁H₂₅ClOS

C₂₁H₂₆OS

tert-butyldimethylsilyl chloride