methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate

Base Information

Chemical Name:methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate
CAS No.:1374132-39-4
Molecular Formula:C₃₂H₃₂F₆N₄O₆
Molecular Weight:682.62
Hs Code.:

methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate

Synonyms:methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate

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Chemical Property of methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate

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Technology Process of methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate

There total 9 articles about methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-methoxyazetidine hydrochloride

: 1393720-94-9
methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfonyl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate

: 1374132-39-4
methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 15823-04-8
methyl 3-(4-methoxyphenyl)propionate

: 1374132-39-4
methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: iodine; silver sulfate / methanol / 1 h / 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; dimethyl sulfoxide / 17 h / 50 - 80 °C / Inert atmosphere

3: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran / 0.33 h / 140 °C / microwave irradiation

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

5: triethylamine / tetrahydrofuran / 20 °C

With iodine; potassium acetate; potassium carbonate; silver sulfate; triethylamine; 3-chloro-benzenecarboperoxoic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1233083-43-6
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one

: 1374132-39-4
methyl 3-{3-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]-4-methoxyphenyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran / 0.33 h / 140 °C / microwave irradiation

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

3: triethylamine / tetrahydrofuran / 20 °C

With potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; dichloromethane;