C₂₇H₂₃ClF₃N₅O₂S

Base Information

• Chemical Name: C₂₇H₂₃ClF₃N₅O₂S
• CAS No.: 1599531-46-0
• Molecular Formula: C₂₇H₂₃ClF₃N₅O₂S
• Molecular Weight: 574.026
• Mol file: 1599531-46-0.mol

Synonyms:C₂₇H₂₃ClF₃N₅O₂S

Chemical Property of C₂₇H₂₃ClF₃N₅O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₃ClF₃N₅O₂S

There total 8 articles about C₂₇H₂₃ClF₃N₅O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,4-dimethylthiazol-5-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol (1599531-44-8) → C27H23ClF3N5O2S (1599531-45-9) + C27H23ClF3N5O2S (1599531-46-0)

Guidance literature:

With Chiralpack OD; In ethanol; n-heptane; Resolution of racemate;

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → C27H23ClF3N5O2S (1599531-45-9) + C27H23ClF3N5O2S (1599531-46-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: L-proline; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / ethanol / 4 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / water / 3.66 h / 70 - 78 °C

3.1: trichlorophosphate / 6.66 h / 100 - 110 °C

4.1: toluene / 118 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.02 h / -70 °C

5.2: 0.77 h / 0 °C

6.1: Chiralpack OD / ethanol; n-heptane / Resolution of racemate

With n-butyllithium; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; trifluoroacetic acid; L-proline; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; n-heptane; water; toluene;

Reference yield:

2,2-dimethyl-5-(4-trifluoromethyl-benzyl)-[1,3]dioxane-4,6-dione (923977-13-3) → C27H23ClF3N5O2S (1599531-45-9) + C27H23ClF3N5O2S (1599531-46-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / water / 3.66 h / 70 - 78 °C

2.1: trichlorophosphate / 6.66 h / 100 - 110 °C

3.1: toluene / 118 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.02 h / -70 °C

4.2: 0.77 h / 0 °C

5.1: Chiralpack OD / ethanol; n-heptane / Resolution of racemate

With n-butyllithium; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; n-heptane; water; toluene;

upstream raw materials:

4-Trifluoromethylbenzaldehyde

2,2-dimethyl-5-(4-trifluoromethyl-benzyl)-[1,3]dioxane-4,6-dione

2-(4-(trifluoromethyl)benzyl)malonic acid

6-bromo-2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinoline