2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ⁶-thia-2,6-diazacyclohex-6-en-3-one

Base Information

Chemical Name:2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ⁶-thia-2,6-diazacyclohex-6-en-3-one
CAS No.:1520120-46-0
Molecular Formula:C₁₃H₁₇FN₂O₂S
Molecular Weight:284.355
Hs Code.:

2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ<sup>6</sup>-thia-2,6-diazacyclohex-6-en-3-one

Synonyms:2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ⁶-thia-2,6-diazacyclohex-6-en-3-one

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Chemical Property of 2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ⁶-thia-2,6-diazacyclohex-6-en-3-one

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Technology Process of 2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ⁶-thia-2,6-diazacyclohex-6-en-3-one

There total 5 articles about 2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ⁶-thia-2,6-diazacyclohex-6-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1520120-17-5
3-{[(4-fluoroanilino)oxo-sec-butyl-1λ⁶-sulfanylidene]amino}propanoic acid

: 1520120-46-0
2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ⁶-thia-2,6-diazacyclohex-6-en-3-one

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1055/s-0033-1339760

Reference yield:

: 1520119-89-4
ethyl 3-{[(4-fluoroanilino)oxo-sec-butyl-1λ⁶-sulfanylidene]amino}propanoate

: 1520120-46-0
2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ⁶-thia-2,6-diazacyclohex-6-en-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / water; tetrahydrofuran / Reflux

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1055/s-0033-1339760

Reference yield:

: 371-40-4
4-fluoroaniline

: 1520120-46-0
2-(4-fluorophenyl)-1-oxo-1-sec-butyl-1λ⁶-thia-2,6-diazacyclohex-6-en-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / toluene / Reflux

2.1: tetrahydrofuran; diethyl ether / 0 °C / Inert atmosphere

3.1: tert-butylhypochlorite / tetrachloromethane / 1.5 h / 0 °C / Inert atmosphere

3.2: 12 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / water; tetrahydrofuran / Reflux

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C / Inert atmosphere

With thionyl chloride; tert-butylhypochlorite; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; toluene;
DOI:10.1055/s-0033-1339760