(2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone

Base Information

Chemical Name:(2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone
CAS No.:1314678-42-6
Molecular Formula:C₁₇H₁₀ClF₃N₄O
Molecular Weight:378.741
Hs Code.:

Synonyms:(2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone

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Chemical Property of (2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone

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Technology Process of (2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone

There total 6 articles about (2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1374423-68-3
C₁₈H₁₀ClF₃N₄O₂

: 1314678-42-6
(2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 1h;
DOI:10.5012/bkcs.2011.32.4.1209

Reference yield:

: 59-67-6
nicotinic acid

: 1314678-42-6
(2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 18 h / 90 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran; toluene / 1 h / 0 °C

2.2: 10 h / 20 °C

3.1: Oxone / methanol / 5 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 5 h / Reflux

5.1: sodium hydroxide / tetrahydrofuran; ethanol / 1 h / 20 °C

With Oxone; isopropylmagnesium chloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.5012/bkcs.2011.32.4.1209

Reference yield:

: 1314678-26-6
(2-methylthiopyrimidin-4-yl)(pyridin-3-yl)methanone

: 1314678-42-6
(2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: Oxone / methanol / 5 h / 0 - 20 °C

2: sodium hydride / tetrahydrofuran / 5 h / Reflux

3: sodium hydroxide / tetrahydrofuran; ethanol / 1 h / 20 °C

With Oxone; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol;
DOI:10.5012/bkcs.2011.32.4.1209