1-(N-acetyl-DL-homocysteinylamino)-6-(benzyloxycarbonylamino)hexane

Base Information

• Chemical Name: 1-(N-acetyl-DL-homocysteinylamino)-6-(benzyloxycarbonylamino)hexane
• CAS No.: 85838-36-4
• Molecular Formula: C₂₀H₃₁N₃O₄S
• Molecular Weight: 409.55
• Mol file: 85838-36-4.mol

Synonyms:1-(N-acetyl-DL-homocysteinylamino)-6-(benzyloxycarbonylamino)hexane

Chemical Property of 1-(N-acetyl-DL-homocysteinylamino)-6-(benzyloxycarbonylamino)hexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(N-acetyl-DL-homocysteinylamino)-6-(benzyloxycarbonylamino)hexane

There total 3 articles about 1-(N-acetyl-DL-homocysteinylamino)-6-(benzyloxycarbonylamino)hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

N-acetyl-DL-homocysteinethiolactone (1195-16-0,768351-04-8,17896-21-8) + monobenzyloxycarbonyl hexamethylenediamine hydrochloride (78618-06-1) → 1-(N-acetyl-DL-homocysteinylamino)-6-(benzyloxycarbonylamino)hexane (85838-36-4)

Guidance literature:

With triethylamine; In ethanol; for 4h;

DOI:10.1016/0008-6215(83)88217-2

Reference yield:

1,6-Hexanediamine (124-09-4) → 1-(N-acetyl-DL-homocysteinylamino)-6-(benzyloxycarbonylamino)hexane (85838-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / 1.) 12 M HCl; 2.) HCl / 1.) methanol, 18 h; 2.) dichloromethane, 0 deg C

2: 51 percent / triethylamine / ethanol / 4 h

With hydrogenchloride; triethylamine; In ethanol;

DOI:10.1016/0008-6215(83)88217-2

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 1-(N-acetyl-DL-homocysteinylamino)-6-(benzyloxycarbonylamino)hexane (85838-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / 1.) 12 M HCl; 2.) HCl / 1.) methanol, 18 h; 2.) dichloromethane, 0 deg C

2: 51 percent / triethylamine / ethanol / 4 h

With hydrogenchloride; triethylamine; In ethanol;

DOI:10.1016/0008-6215(83)88217-2

upstream raw materials:

N-acetyl-DL-homocysteinethiolactone

monobenzyloxycarbonyl hexamethylenediamine hydrochloride

1,6-Hexanediamine

benzyl chloroformate

Downstream raw materials:

1--6-(benzyloxycarbonylamino)hexane