3-Chloro-2-isobutoxypyridine-5-boronic acid pinacol ester

Base Information

• Chemical Name: 3-Chloro-2-isobutoxypyridine-5-boronic acid pinacol ester
• CAS No.: 1387634-81-2
• Molecular Formula: C₁₅H₂₃BClNO₃
• Molecular Weight: 311.617
• Mol file: 1387634-81-2.mol

Synonyms:3-chloro-2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property of 3-Chloro-2-isobutoxypyridine-5-boronic acid pinacol ester

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-chloro-2-(2-methylpropoxy)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-2-isobutoxypyridine-5-boronic acid pinacol ester

There total 6 articles about 3-Chloro-2-isobutoxypyridine-5-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-bromo-3-chloro-2-isobutoxypyridine (1289093-31-7) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 3-chloro-2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1387634-81-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In 1,4-dioxane; for 4h; Reflux;

Reference yield: 48.1%

5-bromo-3-chloro-2-isobutoxypyridine (1289093-31-7) + bis(pinacol)diborane (73183-34-3) → 3-chloro-2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1387634-81-2)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 90 ℃; Inert atmosphere;

Reference yield:

3-chloro-2-isobutoxy-pyridine (1288989-54-7) + bis(pinacol)diborane (73183-34-3) → 3-chloro-2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1387634-81-2)

Guidance literature:

(1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

upstream raw materials:

5-bromo-3-chloro-2-isobutoxypyridine

bis(pinacol)diborane

3-chloro-2-isobutoxy-pyridine

5-bromo-3-chloro-2-fluoropyridine

Downstream raw materials:

5-chloro-6-isobutoxypyridin-3-ol

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