Se-phenyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

Base Information

• Chemical Name: Se-phenyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboselenoate
• CAS No.: 879612-37-0
• Molecular Formula: C₂₆H₂₀N₂OSe
• Molecular Weight: 455.418
• Mol file: 879612-37-0.mol

Synonyms:Se-phenyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

Chemical Property of Se-phenyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Se-phenyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

There total 5 articles about Se-phenyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboselenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-3-quinolin-3-ylmethyl-1H-indole-2-carboxylic acid + Phenylselenyl chloride (5707-04-0) → Se-phenyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboselenoate (879612-37-0)

Guidance literature:

1-methyl-3-quinolin-3-ylmethyl-1H-indole-2-carboxylic acid; With triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

Phenylselenyl chloride; With tributylphosphine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol052600e

Reference yield:

methyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboxylate (879612-34-7) → Se-phenyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboselenoate (879612-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LiOH / tetrahydrofuran; H₂O / 5 h / 65 °C

2.1: Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

2.2: PBu₃ / tetrahydrofuran / 20 °C

With lithium hydroxide; triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ol052600e

Reference yield:

methyl 3-[(2-bromo-3-quinolyl)methyl]-1-methyl-2-indolecarboxylate (879612-32-5) → Se-phenyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboselenoate (879612-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / Bu₃SnH; AIBN / benzene / 2 h / Heating

2.1: LiOH / tetrahydrofuran; H₂O / 5 h / 65 °C

3.1: Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

3.2: PBu₃ / tetrahydrofuran / 20 °C

With lithium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In tetrahydrofuran; dichloromethane; water; benzene;

DOI:10.1021/ol052600e

upstream raw materials:

Phenylselenyl chloride

methyl 1-methyl-3-[(3-quinolyl)methyl]-2-indolecarboxylate

methyl 3-[(2-bromo-3-quinolyl)methyl]-1-methyl-2-indolecarboxylate

2-bromoquinoline