- Chemical Name:Sesbanimide
- CAS No.:85719-78-4
- Molecular Formula:C15H21NO7
- Molecular Weight:327.334
- Hs Code.:
- Mol file:85719-78-4.mol
Synonyms:
Synonyms:
Sesbanimide A *data from reagent suppliers
There total 138 articles about Sesbanimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 100.0%
Reference yield: 86.0%
Reference yield: 82.0%
This study focused on the synthesis and antitumor activity of the AB ring system enantiomers of Sesbanimide A, a potent antitumor alkaloid isolated from the seeds of Sesbania drummondii and S. punices. The researchers efficiently synthesized the fully unprotected AB ring system enantiomers from readily available D- and L-xylose. The synthetic route involved several steps, including hydroxyl protection, ring opening and carbon chain extension, construction of the dioxane ring, Michael addition, demethoxycarbonylation, and catalytic hydrogenation. The synthesized compounds were then tested for in vitro antitumor activity against P388 murine leukemia, and the results showed that the AB ring system itself contributed little to the cytotoxicity of Sesbanimide A, indicating that the significant antitumor activity of Sesbanimide A mainly comes from its characteristic C ring.