methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

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Chemical Name:methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate
CAS No.:1416718-16-5
Molecular Formula:C₄₃H₄₉N₉O₆S
Molecular Weight:819.985
Hs Code.:

methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Synonyms:methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

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Chemical Property of methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

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Technology Process of methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

There total 5 articles about methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1007877-71-5,1353887-53-2
(R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride

: 1416718-31-4
methyl (S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(6-(3-(S)-pyrrolidine-2-carbonylureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-ylcarbamate

: 1416718-16-5
methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 2516-37-2
2-bromo-6-nitro-benzo[d]thiazole

: 1416718-16-5
methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; iron / 24 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

2.3: 20 h / 20 °C

3.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 8 h / 80 °C / Inert atmosphere; Sealed vessel

4.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With iron; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; HATU; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 945400-80-6
2-bromanyl-1,3-benzothiazol-6-amine

: 1416718-16-5
methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

1.3: 20 h / 20 °C

2.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 8 h / 80 °C / Inert atmosphere; Sealed vessel

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; HATU; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;