(R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride

Base Information

• Chemical Name: (R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride
• CAS No.: 1007877-71-5
• Molecular Formula: C₁₀H₁₃NO₂*ClH
• Molecular Weight: 215.68

Synonyms:(R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride

Chemical Property of (R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

(R)-alpha-(Dimethylamino)benzeneacetic acid HCl 95+% ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride

There total 1 articles about (R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (R)-phenylglycine (875-74-1) → (R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride (1007877-71-5,1353887-53-2)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; for 24h; under 760.051 Torr;

DOI:10.1016/j.bmc.2014.06.027

Reference yield: 88.0%

(R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride (1007877-71-5,1353887-53-2) + (2S)-N-[4-(5-{4-[(2S)-pyrrolidine-2-amido]phenyl}-1,3-oxazol-2-yl)phenyl]-pyrrolidine-2-carboxamide hydrochloride + trifluoroacetic acid (76-05-1) → (2S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-N-[4-(2-{4-[(2S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]pyrrolidine-2-amido]phenyl}-1,3-oxazol-5-yl)phenyl]pyrrolidine-2-carboxamide trifluoroacetate

Guidance literature:

(R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride; (2S)-N-[4-(5-{4-[(2S)-pyrrolidine-2-amido]phenyl}-1,3-oxazol-2-yl)phenyl]-pyrrolidine-2-carboxamide hydrochloride; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere;

trifluoroacetic acid; In methanol; water; N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1021/jm4016203

Reference yield: 62.0%

(R)-2-(dimethylamino)-2-phenylacetic acid hydrochloride (1007877-71-5,1353887-53-2) + 1-(4-bromophenyl)-3-((S)-pyrrolidine-2-carbonyl)urea hydrochloride (1416718-23-4) → 1-(4-bromophenyl)-3-[(S)-1-((R)-2-dimethylamino-2-phenylacetyl)pyrrolidine-2-carbonyl]urea (1416718-29-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

upstream raw materials:

formaldehyd

(R)-phenylglycine

Downstream raw materials:

(R)-1-((S)-2-(6-(2-azidoacetyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)-2-(dimethylamino)-2-phenylethanone

methyl (S)-1-((S)-2-(5-(4-(6-(3-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carbonyl)ureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

1-(4-bromophenyl)-3-[(S)-1-((R)-2-dimethylamino-2-phenylacetyl)pyrrolidine-2-carbonyl]urea

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