2-(4-methoxyphenyl)-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine
• CAS No.: 359785-71-0
• Molecular Formula: C₃₆H₅₂N₄O₅Si₂
• Molecular Weight: 677.004

Synonyms:2-(4-methoxyphenyl)-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Chemical Property of 2-(4-methoxyphenyl)-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Chemical Property:

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Technology Process of 2-(4-methoxyphenyl)-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

There total 1 articles about 2-(4-methoxyphenyl)-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-methoxyphenylboronic acid (5720-07-0) + 2-bromo-6-benzyloxy-9-[2-deoxy-3,5-bis(O-tert-butyldimethylsilyl)-β-D-erythro-pentofuranosyl]purine (236427-58-0) → 2-(4-methoxyphenyl)-O6-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine (359785-71-0)

Guidance literature:

With palladium diacetate; potassium phosphate; CyJohnPhos; In 1,4-dioxane; at 100 ℃; for 6h;

DOI:10.1021/ja0107172

Reference yield: 86.0%

2-(4-methoxyphenyl)-O6-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine (359785-71-0) → 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-(4-methoxy-phenyl)-1,9-dihydro-purin-6-one

Guidance literature:

With hydrogen; 5percent Pd/C; In tetrahydrofuran; methanol; at 20 ℃; under 760.051 Torr;

DOI:10.1021/ja0107172

upstream raw materials:

4-methoxyphenylboronic acid

2-bromo-6-benzyloxy-9-[2-deoxy-3,5-bis(O-tert-butyldimethylsilyl)-β-D-erythro-pentofuranosyl]purine

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