ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate

Base Information

Chemical Name:ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate
CAS No.:1241898-70-3
Molecular Formula:C₁₉H₁₇F₃N₆O₃S
Molecular Weight:466.444
Hs Code.:

Synonyms:ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate

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Chemical Property of ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate

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Technology Process of ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate

There total 2 articles about ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241897-90-4
ethyl [5-(2-bromo-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate

: 1241898-69-0
azetidin-3-yl[2-(trifluoromethyl)phenyl]methanone hydrochloride

: 1241898-70-3
ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 0.25h; Sealed tube; Microwave irradiation;

Reference yield:

: 1241898-68-9
tert-butyl 3-[2-(trifluoromethyl)benzoyl]azetidine-1-carboxylate

: 1241898-70-3
ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethyl acetate; 1-methyl-pyrrolidin-2-one / 0.25 h / 120 °C / Microwave; Sealed tube

With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethyl acetate;

Reference yield:

: 1241898-70-3
ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate

: 1241896-49-0
[5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetic acid

Guidance literature:: ethyl [5-(2-{3-[2-(trifluoromethyl)benzoyl]azetidin-1-yl}-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With acetic acid; In tetrahydrofuran; water;