4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide

Base Information

Chemical Name:4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide
CAS No.:1355656-79-9
Molecular Formula:C₂₄H₂₆ClN₃O₅S
Molecular Weight:504.007
Hs Code.:

Synonyms:4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide

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Chemical Property of 4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide

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Technology Process of 4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide

There total 4 articles about 4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3144-09-0
methanesulfonamide

: 1355656-59-5
4-(4-chloro-3-ethylphenoxy)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzaldehyde

: 1355656-79-9
4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide

Guidance literature:: With bis(tertbutylcarbonyloxy)iodobenzene; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; In Isopropyl acetate; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 77771-02-9
3-bromo-4-fluorobenzaldehyde

: 1355656-79-9
4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.02 h

1.2: 5 h / 50 °C

2.1: caesium carbonate / 1,4-dioxane; water / 18 h / 75 °C / Inert atmosphere

3.1: bis(tertbutylcarbonyloxy)iodobenzene / bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / Isopropyl acetate / 2 h / 20 °C / Inert atmosphere

With bis(tertbutylcarbonyloxy)iodobenzene; potassium carbonate; caesium carbonate; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; In 1,4-dioxane; Isopropyl acetate; water; dimethyl sulfoxide;

Reference yield:

: 14143-32-9
4-chloro-3-ethylphenol

: 1355656-79-9
4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.02 h

1.2: 5 h / 50 °C

2.1: caesium carbonate / 1,4-dioxane; water / 18 h / 75 °C / Inert atmosphere

3.1: bis(tertbutylcarbonyloxy)iodobenzene / bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / Isopropyl acetate / 2 h / 20 °C / Inert atmosphere

With bis(tertbutylcarbonyloxy)iodobenzene; potassium carbonate; caesium carbonate; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; In 1,4-dioxane; Isopropyl acetate; water; dimethyl sulfoxide;