(4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester

Base Information

• Chemical Name: (4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester
• CAS No.: 109089-89-6
• Molecular Formula: C₁₇H₁₈O₄
• Molecular Weight: 286.328
• Mol file: 109089-89-6.mol

Synonyms:(4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester

Chemical Property of (4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester

There total 5 articles about (4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethanol (64-17-5) + α-Hydroxy-4-(phenylmethoxy)benzeneacetonitrile (58327-40-5,189683-89-4) → (4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester (109089-89-6)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 5 ℃; for 24h;

DOI:10.1021/jm9800402

Reference yield: 85.0%

ethyl 2-(4-(benzyloxy)phenyl)-2-diazoacetate → (4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester (109089-89-6)

Guidance literature:

With C₁₈BF₁₅*(x)H₂O; water; at 40 ℃; for 0.5h; Sealed tube; Schlenk technique;

DOI:10.1021/acs.orglett.8b01988

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → (4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester (109089-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / aq. NH₄Cl / diethyl ether / 24 h / 5 °C

2: 88 percent / HCl / diethyl ether / 24 h / 5 °C

With hydrogenchloride; ammonium chloride; In diethyl ether;

DOI:10.1021/jm9800402

upstream raw materials:

ethanol

α-Hydroxy-4-(phenylmethoxy)benzeneacetonitrile

p-benzyloxybenzaldehyde

ethyl 3-(benzyloxyphenyl)acetate

Downstream raw materials:

(4-(benzyloxy)phenyl)chloroacetic acid ethyl ester

Refernces

• 1、 Kucznierz, Ralf,Grams, Frank,Leinert, Herbert,Marzenell, Klaus,Engh, Richard A.,Von der Saal, Wolfgang. "Tetrahydro-isoquinoline-based factor Xa inhibitors". . p. 4983 - 4994. Retrieved 2007/10/03.