1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone

Base Information

• Chemical Name: 1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone
• CAS No.: 355387-55-2
• Molecular Formula: C₁₄H₁₇F₃O₃
• Molecular Weight: 290.282
• Mol file: 355387-55-2.mol

Synonyms:1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone

Chemical Property of 1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone

There total 8 articles about 1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trifluoroacetic anhydride (407-25-0) + 2,4-di-n-propylbenzene-1,3-diol (355387-54-1) → 1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone (355387-55-2)

Guidance literature:

With aluminium trichloride; In dichloromethane;

DOI:10.1016/S0960-894X(03)00702-9

Reference yield: 92.4%

trifluoroacetic anhydride (407-25-0) + 2,4-di-n-propylbenzene-1,3-diol (355387-54-1) → trifluoro-acetic acid 3-hydroxy-2,4-dipropyl-phenyl ester + 1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone (355387-55-2)

Guidance literature:

trifluoroacetic anhydride; 2,4-di-n-propylbenzene-1,3-diol; With trifluorormethanesulfonic acid; In toluene; at 30 - 40 ℃; for 2h;

With methanol; water; In toluene; at 45 ℃; for 2h;

DOI:10.1021/jo051027+

Reference yield:

2,4-diallyl-1,3-benzenediol (71489-64-0) → 1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone (355387-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethyl acetate / 1.5 h / 20 °C / 2068.59 Torr

2: 1139.8 g / AlCl₃ / CH₂Cl₂ / 20 °C

With aluminium trichloride; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1021/jm048993p

upstream raw materials:

trifluoroacetic anhydride

2,4-di-n-propylbenzene-1,3-diol

2,4-diallyl-1,3-benzenediol

1,3-bis(allyloxy)benzene

Downstream raw materials:

(S)-(5,7-Dipropyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-phenyl-acetic acid (S)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

(5,7-dipropyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-[4-(pyridin-2-ylmethoxy)-phenyl]-acetic acid methyl ester

(5,7-dipropyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-(4-isopropyl-phenyl)-acetic acid methyl ester

(4-chloro-phenyl)-(5,7-dipropyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-acetic acid methyl ester