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Usage

Uses

Used in Fragrance Industry:
2,4-di-2-propen-1-yl-1,3-Benzenediol is used as a scent and flavoring agent in the fragrance industry. Its unique aroma and flavor profile contribute to the creation of various fragrances and flavorings in products such as perfumes, candles, and food items.
Used in Pharmaceutical Formulations:
In the pharmaceutical industry, 2,4-di-2-propen-1-yl-1,3-Benzenediol is used as a potential therapeutic agent due to its antioxidant, anti-inflammatory, and anticancer properties. Its ability to modulate various biological pathways and exhibit synergistic effects with conventional drugs makes it a valuable compound for the development of new medications.
Used in Cosmetic Formulations:
2,4-di-2-propen-1-yl-1,3-Benzenediol is also utilized in cosmetic formulations for its potential benefits to skin health. Its antioxidant and anti-inflammatory properties may contribute to the development of skincare products that promote skin health and address various skin concerns.
Overall, 2,4-di-2-propen-1-yl-1,3-Benzenediol is a multifaceted compound with a wide range of applications in industries such as fragrance, pharmaceutical, and cosmetics. Its unique properties and potential therapeutic effects make it a valuable asset for the development of innovative products and treatments.

Upstream product

• 13594-95-1 1,3-bis(allyloxy)benzene 
• 108-46-3 recorcinol 
• 107-18-6 allyl alcohol 

Downstream Products

• 355387-55-2 1-(2,4-dihydroxy-3,5-dipropylphenyl)-2,2,2-trifluoroethanone 
• 355387-56-3 2,4-dihydroxy-3,5-dipropyl-1',1',1'-trifluoroacetophenone oxime 
• 1186118-36-4 1,5-dimethyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)-5-phenylimidazolidine-2,4-dione 
• 1186118-03-5 5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)-butyl)-5-phenylimidazolidine-2,4-dione 
• 1186118-11-5 5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)-butyl)-5-p-tolylimidazolidine-2,4-dione 
• 1186118-04-6 5-(2-methoxyphenyl)-5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione 
• 1186118-05-7 5-(4-methoxyphenyl)-5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione 
• 1186118-06-8 5-(4-methoxyphenyl)-5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione 
• 1186118-22-8 5-(3,4-dimethoxyphenyl)-5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione 
• 1186118-18-2 5-(4-(dimethylamino)phenyl)-5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione 
• 1186116-20-0 5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)-5-(4-(trifluoromethyl)phenyl)imidazolidine-2,4-dione 
• 1186118-17-1 5-methyl-5-(4-nitrophenyl)-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione 
• 1186118-21-7 4-(4-methyl-2,5-dioxo-1-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidin-4-yl)benzoic acid 
• 1186116-23-3 5-(4-hydroxyphenyl)-5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione 

Relevant academic research and scientific papers

Design and discovery of 2-oxochromene derivatives as liver X receptor β-selective agonists

In an attempt to molecularly design liver X receptor (LXR) β-selective agonists, we discovered that the combination of the 2-oxochromene moiety (head) and the imidazoline-2,4-dione moiety (tail) plays an important role in the expression potency and select

An expedient synthesis of bis-fused benzofuran and a two-directional ring- closing metathesis for the synthesis of bisbenzoxepines and bisbenzoxocines

Synthesis of bis-fused benzofuran derivatives by the implementation of palladium-mediated intramolecular cyclization is described. To our knowledge, this is the first report of the synthesis of bis-fused benzofuran by this protocol. Bisbenzoxepine and bis

Effect of ortho-SR groups on O-H bond strength and H-atom donating ability of phenols: A possible role for the tyr-cys link in galactose oxidase active site?

Rotation about the Ar-S bond in ortho-(alkylthio)phenols strongly affects the bond dissociation enthalpy (BDE) and the reactivity of the OH group. Newly synthesized sulfur containing heterocycles 3 and 4, where the -SR group is almost coplanar with the phenolic ring, are characterized by unusually low BDE(O-H) values (79.6 and 79.2 kcal/mol, respectively) and by much higher reactivities toward peroxyl radicals than the ortho-methylthio derivative 1 (82.0 kcal/mol). The importance of the intramolecular hydrogen bond (IHB) in determining the BDE(O-H) was demonstrated by FT-IR experiments, which showed that in heterocycles 3 and 4 the IHB between the phenolic OH group and the S atom is much weaker than that present in 1. Since the IHB can be formed only if the -SR group adopts an out-of-plane geometry, this interaction is possible only in the methylthio derivative 1 and not in 3 and 4. The additive contribution to the phenolic BDE(O-H) of the -SR substituent therefore varies from -3.1 to +2.8 kcal/mol for the in-plane and out-of-plane conformations, respectively. These results may be relevant to understanding the role of the tyrosine-cysteine link in the active site of galactose oxidase, an important enzyme that catalyzes the two-electron aerobic oxidation of primary alcohols to aldehydes. The switching of the ortho -SR substituent between perpendicular and planar conformations may account for the catalytic efficiency of this enzyme.

Novel synthesis of medium-sized oxa-heterocycles by palladium-catalyzed intramolecular Heck reaction

An efficient and high yielding method for the synthesis of eight-membered heterocyclic skeletons has been developed via palladium-catalyzed intramolecular Heck reaction.

Palladium-catalyzed, triethylborane-promoted C-allylation of naphthols and benzene polyols by direct use of allyl alcohols

The combination of a catalytic amount of Pd(0) species and triethylborane promotes the C-allylation of benzene polyols and naphthols at room temperature to 50 °C by the direct use of a variety of allylic alcohols; Exhaustive allylation of 1,3-benzenediol and 1,3,5-benzenetriol provides penta-allylation and hexa-allylation products, respectively, in good yields. Georg Thieme Verlag Stuttgart.

Discovery of a novel series of peroxisome proliferator-activated receptor α/γ dual agonists for the treatment of type 2 diabetes and dyslipidemia

A series of 2-aryloxy-2-methyl-propionic acid compounds and related analogues were designed, synthesized, and evaluated for their PPAR agonist activities. 2-[(5,7-Dipropyl-3-trifluoromethyl)-benzisoxazol-6-yloxy]-2- methylpropionic acid (4) was identified

Aryloxyacetic acids for diabetes and lipid disorders

A class of aryloxyacetic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyper

Aryloxyacetic acids for diabetes and lipid disorders

A class of aryloxyacetic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyper