tert-butyl 2,2',2-(10-(1-(benzyloxycarbonylamino)-2-methoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

• Chemical Name: tert-butyl 2,2',2-(10-(1-(benzyloxycarbonylamino)-2-methoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
• CAS No.: 914455-39-3
• Molecular Formula: C₃₇H₆₁N₅O₁₀
• Molecular Weight: 735.919
• Mol file: 914455-39-3.mol

Synonyms:tert-butyl 2,2',2-(10-(1-(benzyloxycarbonylamino)-2-methoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Chemical Property of tert-butyl 2,2',2-(10-(1-(benzyloxycarbonylamino)-2-methoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2,2',2-(10-(1-(benzyloxycarbonylamino)-2-methoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 4 articles about tert-butyl 2,2',2-(10-(1-(benzyloxycarbonylamino)-2-methoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl N-(benzyloxycarbonyl)-α-bromoglycinate (127382-97-2) + 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane (122555-91-3) → tert-butyl 2,2',2-(10-(1-(benzyloxycarbonylamino)-2-methoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (914455-39-3)

Guidance literature:

With potassium carbonate; In acetonitrile; at 70 ℃; for 6h;

DOI:10.1016/j.tetlet.2006.08.019

Reference yield:

O-benzyl carbamate (621-84-1) → tert-butyl 2,2',2-(10-(1-(benzyloxycarbonylamino)-2-methoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (914455-39-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / diethyl ether / 144 h / 20 °C

2: 95 percent / H₂SO₄ / 48 h / 20 °C

3: 75 percent / PBr₃ / CCl₄ / 168 h / 20 °C

4: 90 percent / K₂CO₃ / acetonitrile / 6 h / 70 °C

With sulfuric acid; phosphorus tribromide; potassium carbonate; In tetrachloromethane; diethyl ether; acetonitrile;

DOI:10.1016/j.tetlet.2006.08.019

Reference yield:

methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate (127357-37-3,58237-86-8) → tert-butyl 2,2',2-(10-(1-(benzyloxycarbonylamino)-2-methoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (914455-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / PBr₃ / CCl₄ / 168 h / 20 °C

2: 90 percent / K₂CO₃ / acetonitrile / 6 h / 70 °C

With phosphorus tribromide; potassium carbonate; In tetrachloromethane; acetonitrile;

DOI:10.1016/j.tetlet.2006.08.019

upstream raw materials:

methyl N-(benzyloxycarbonyl)-α-bromoglycinate

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

O-benzyl carbamate

methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate