Dosulepin hydrochloride

Base Information

• Chemical Name: Dosulepin hydrochloride
• CAS No.: 897-15-4
• Molecular Formula: C19H21 N S . Cl H
• Molecular Weight: 331.909
• European Community (EC) Number: 212-978-8
• DSSTox Substance ID: DTXSID50873549
• Wikidata: Q27116968
• NCI Thesaurus Code: C78018
• ChEMBL ID: CHEMBL2361409
• Mol file: 897-15-4.mol

Synonyms:Dosulepin;Dothiepin;Dothiepin Hydrochloride;Hydrochloride, Dothiepin;Prothiaden

Chemical Property of Dosulepin hydrochloride

Chemical Property:

• Appearance/Colour: Crystalline powder
• Vapor Pressure: 8.68E-09mmHg at 25°C
• Melting Point: 218-221ºC
• Boiling Point: 430.9 °C at 760 mmHg
• Flash Point: 214.4 °C
• PSA: 28.54000
• LogP: 5.47770
• Storage Temp.: ?20°C
• Solubility.: Freely soluble in water, in alcohol and in methylene chloride.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 331.1161486
• Heavy Atom Count: 22
• Complexity: 363

Purity/Quality:

99%, ^*data from raw suppliers

DothiepinHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T,Xn
• Hazard Codes: F,T,Xn
• Statements: 11-23/24/25-39/23/24/25-22
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31.Cl
• Isomeric SMILES: CN(C)CC/C=C\1/C2=CC=CC=C2CSC3=CC=CC=C31.Cl
• Recent EU Clinical Trials: Establish limits for fitness to drive with prolonged use of ICADTS class III medication
• Uses: Dothiepin Hydrochloride is a tricyclic antidepressant. Monoamine reuptake inhibitor; tricyclic antidepressant
• Drug interactions: Potentially hazardous interactions with other drugsAlcohol: increased sedative effect.Analgesics: increased risk of CNS toxicity with tramadol; possibly increased risk of side effects with nefopam; possibly increased sedative effects with opioids.Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone - avoid; increased risk of ventricular arrhythmias with disopyramide, dronedarone, flecainide or propafenone - avoid with dronedarone.Antibacterials: increased risk of ventricular arrhythmias with moxifloxacin and possibly delamanid and telithromycin - avoid with moxifloxacin.Anticoagulants: may alter anticoagulant effect of coumarins.Antidepressants: enhanced CNS excitation and hypertension with MAOIs and moclobemide - avoid; concentration possibly increased with SSRIs; risk of ventricular arrhythmias with citalopram and escitalopram - avoid; possible increased risk of convulsions with vortioxetine.Antiepileptics: convulsive threshold lowered; concentration reduced by carbamazepine, phenobarbital and possibly fosphenytoin, phenytoin and primidone.Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.Antipsychotics: increased risk of ventricular arrhythmias especially with droperidol, fluphenazine, haloperidol, pimozide, risperidone, sulpiride and zuclopenthixol - avoid; increased antimuscarinic effects with clozapine and phenothiazines; concentration increased by antipsychoticsAntivirals: increased risk of ventricular arrhythmias with saquinavir - avoid; concentration possibly increased with ritonavir.Atomoxetine: increased risk of ventricular arrhythmias and possibly convulsions.Beta-blockers: increased risk of ventricular arrhythmias with sotalol.Clonidine: tricyclics antagonise hypotensive effect; increased risk of hypertension on clonidine withdrawal.Dapoxetine: possible increased risk of serotonergic effects - avoidDopaminergics: avoid use with entacapone; CNS toxicity reported with selegiline and rasagiline.

Technology Process of Dosulepin hydrochloride

There total 1 articles about Dosulepin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dothiepin (113-53-1,25627-37-6,25627-38-7) → dothiepin hydrochloride (897-15-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; ethanol;

Reference yield:

dothiepin hydrochloride (897-15-4) → 11-(3-Methylamino-propyliden)-6,11-dihydro-dibenzothiepin (1154-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 1.) NaHCO₃ / toluene / 6 h / Heating

2: 77 percent / KOH / butan-1-ol / 4 h / Heating

With potassium hydroxide; sodium hydrogencarbonate; In toluene; butan-1-ol;

DOI:10.1248/cpb.41.1987

upstream raw materials:

dothiepin

Downstream raw materials:

11-(3-Methylamino-propyliden)-6,11-dihydro-dibenzothiepin