(2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol

Base Information

Chemical Name:(2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol
CAS No.:1215192-68-9
Molecular Formula:C₂₄H₃₀F₂N₄O₃
Molecular Weight:460.524
Hs Code.:

(2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol

Synonyms:(2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol

Suppliers and Price of (2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol

There total 10 articles about (2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1215192-67-8
4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

: 1215192-68-9
(2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol

Guidance literature:: With maleic acid; In water; acetonitrile; at 20 ℃; for 24h; Reagent/catalyst; Concentration; Solvent; Temperature; Time;

Reference yield:

: 1215192-65-6
(3aR,4R,5R,6aS)-5-((t-butyldimethylsilyl)oxy)-4-((3R,4R,E)-3-((t-butyldimethylsilyl)oxy)-4-(m-tolyl)pent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one

: 1215192-68-9
(2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1: N-fluorobis(benzenesulfon)imide; manganese(II) bromide; potassium hexamethylsilazane / toluene; tetrahydrofuran / 3.5 h / 0 °C

2: potassium hexamethylsilazane / toluene / 18 h / -10 °C

3: acetic acid / water; tetrahydrofuran / 46 h / 35 °C

With manganese(II) bromide; potassium hexamethylsilazane; acetic acid; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; water; toluene;

Reference yield:

: 213406-28-1,601472-22-4
(R)-2-(3-methylphenyl)propionic acid

: 1215192-68-9
(2Z,3aR,4R,5R,6aS)-3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(1H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / 6 h / Reflux

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 °C

3.1: sodium hydride / 1,2-dimethoxyethane / 1 h

3.2: 1 h

4.1: (-)-diisopinocampheyl chloride / hexane; tetrahydrofuran; acetone / -40 °C / Cooling with ice

5.1: potassium carbonate / methanol / 17 h / 20 °C

5.2: pH 7

6.1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h

7.1: N-fluorobis(benzenesulfon)imide; manganese(II) bromide; potassium hexamethylsilazane / toluene; tetrahydrofuran / 3.5 h / 0 °C

8.1: potassium hexamethylsilazane / toluene / 18 h / -10 °C

9.1: acetic acid / water; tetrahydrofuran / 46 h / 35 °C

With 1H-imidazole; manganese(II) bromide; n-butyllithium; (-)-diisopinocampheyl chloride; sulfuric acid; potassium hexamethylsilazane; sodium hydride; potassium carbonate; acetic acid; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; water; N,N-dimethyl-formamide; acetone; toluene;