4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

Base Information

Chemical Name:4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane
CAS No.:1215192-67-8
Molecular Formula:C₃₆H₅₈F₂N₄O₃Si₂
Molecular Weight:689.049
Hs Code.:

4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

Synonyms:4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

Suppliers and Price of 4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

There total 9 articles about 4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1215192-66-7
(3aR,4R,5R,6aS)-5-((t-butyldimethylsilyl)oxy)-4-((3R,4R,E)-3-((t-butyldimethylsilyl)oxy)-4-(m-tolyl)pent-1-en-1-yl)-3,3-difluorohexahydro-2H-cyclopenta[b]furan-2-one

: 42743-15-7
4-(tetrazol-5-yl)-butyltriphenylphosphonium bromide

: 1215192-67-8
4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

Guidance literature:: 4-(tetrazol-5-yl)-butyltriphenylphosphonium bromide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 20 - 60 ℃; for 1h;

(3aR,4R,5R,6aS)-5-((t-butyldimethylsilyl)oxy)-4-((3R,4R,E)-3-((t-butyldimethylsilyl)oxy)-4-(m-tolyl)pent-1-en-1-yl)-3,3-difluorohexahydro-2H-cyclopenta[b]furan-2-one; In tetrahydrofuran; toluene; at -15 - 0 ℃; for 20.5h;

Reference yield:

: (R)-2-(3-methylphenyl)propionic acid methyl ester

: 1215192-67-8
4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 2 h / -78 °C

2.1: sodium hydride / 1,2-dimethoxyethane / 1 h

2.2: 1 h

3.1: (-)-diisopinocampheyl chloride / hexane; tetrahydrofuran; acetone / -40 °C / Cooling with ice

4.1: potassium carbonate / methanol / 17 h / 20 °C

4.2: pH 7

5.1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h

6.1: N-fluorobis(benzenesulfon)imide; manganese(II) bromide; potassium hexamethylsilazane / toluene; tetrahydrofuran / 3.5 h / 0 °C

7.1: potassium hexamethylsilazane / toluene / 18 h / -10 °C

With 1H-imidazole; manganese(II) bromide; n-butyllithium; (-)-diisopinocampheyl chloride; potassium hexamethylsilazane; sodium hydride; potassium carbonate; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1215192-63-4
(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-hydroxy-4-(m-tolyl)-1-pentenyl]-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one

: 1215192-67-8
4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-t-butyldimethylsiloxy-4-(m-tolyl)-1-pentenyl]-7-t-butyldimethylsiloxy-2-oxa-4,4-difluoro-bicyclo[3.3.0]octan-3-ylidene]-1-(tetrazol-5-yl)butane

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / methanol / 17 h / 20 °C

1.2: pH 7

2.1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h

3.1: N-fluorobis(benzenesulfon)imide; manganese(II) bromide; potassium hexamethylsilazane / toluene; tetrahydrofuran / 3.5 h / 0 °C

4.1: potassium hexamethylsilazane / toluene / 18 h / -10 °C

With 1H-imidazole; manganese(II) bromide; potassium hexamethylsilazane; potassium carbonate; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;