ANGIOTENSIN I/II (4-8)

Base Information

• Chemical Name: ANGIOTENSIN I/II (4-8)
• CAS No.: 52530-60-6
• Molecular Formula: C35H45 N7 O7
• Molecular Weight: 675.7745
• Mol file: 52530-60-6.mol

Synonyms:3-7-AngiotensinIII, 4-L-isoleucine- (9CI); Alanine,3-phenyl-N-[1-[N-(N-tyrosylisoleucyl)histidyl]prolyl]- (6CI); L-Phenylalanine,N-[1-[N-(N-L-tyrosyl-L-isoleucyl)-L-histidyl]-L-prolyl]-; 10: PN: US20090227507SEQID: 19 unclaimed protein; 15: PN: WO0056345 SEQID: 15 claimed sequence; 15:PN: WO0198325 SEQID: 15 claimed protein; 16: PN: US20030130196 SEQID: 15claimed protein; 1: PN: WO0143761 SEQID: 15 unclaimed sequence; 1: PN:WO02087504 SEQID: 15 unclaimed sequence; 20: PN: WO9958140 SEQID: 15 claimedsequence; 28: PN: WO03011304 TABLE: 2 claimed protein; 2: PN: US6248587 SEQID:15 unclaimed sequence; 2: PN: WO0144270 SEQID: 15 unclaimed sequence; 2: PN:WO0206308 SEQID: 15 unclaimed sequence; 37: PN: US20080293634 SEQID: 44unclaimed sequence; 459: PN: WO0069900 SEQID: 645 unclaimed sequence; 50: PN:WO0155176 SEQID: 14 unclaimed protein; 535: PN: US20090175821 SEQID: 645 claimedprotein; 8: PN: US6762167 SEQID: 15 unclaimed sequence; 9: PN: US6335195 SEQID:15 unclaimed sequence; Human angiotensin pentapeptide(4-8)

Chemical Property of ANGIOTENSIN I/II (4-8)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.617
• Boiling Point: 1107.2 °C at 760 mmHg
• PKA: 3.56±0.10(Predicted)
• Flash Point: 623.4 °C
• PSA: 219.84000
• Density: 1.316 g/cm³
• LogP: 2.85750
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

Angiotensin I/II (4-8) H-Tyr-Ile-His-Pro-Phe-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ANGIOTENSIN I/II (4-8)

There total 5 articles about ANGIOTENSIN I/II (4-8) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Tyr(t-Bu)-Ile-His(Trt)-Pro-Phe-OH (192389-07-4) → angiotensin II-(4-8) (52530-60-6)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In dichloromethane; Yield given;

Reference yield:

N-Fmoc L-Phe (35661-40-6) → angiotensin II-(4-8) (52530-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 2-chlorotrityl chloride resin, (i-Pr)2EtN, 2-4.) a)piperidine, b) DCC, HOBt, 5.) AcOH, TFE / solid phase peptide synthesis

2: TFA, anisole / CH₂Cl₂

With piperidine; 2-chlorotrityl chloride resin; 2,2,2-trifluoroethanol; benzotriazol-1-ol; acetic acid; methoxybenzene; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

Reference yield:

Fmoc-Ile-OH (71989-23-6,251316-98-0) → angiotensin II-(4-8) (52530-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 2-chlorotrityl chloride resin, (i-Pr)2EtN, 2-4.) a)piperidine, b) DCC, HOBt, 5.) AcOH, TFE / solid phase peptide synthesis

2: TFA, anisole / CH₂Cl₂

With piperidine; 2-chlorotrityl chloride resin; 2,2,2-trifluoroethanol; benzotriazol-1-ol; acetic acid; methoxybenzene; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

Fmoc-Tyr(t-Bu)-Ile-His(Trt)-Pro-Phe-OH

N-Fmoc L-Phe

Fmoc-Ile-OH

Fmoc-His(Trt)-OH