Technology Process of (2S,11S,12R)-7-Benzenesulfonyl-12-isobutyl-13-oxo-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide
There total 7 articles about (2S,11S,12R)-7-Benzenesulfonyl-12-isobutyl-13-oxo-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2 / Pd/C / methanol / 3 h
2: 90 percent / BOP; DIEA / dimethylformamide
3: 55 percent / DIAD; PPh3 / tetrahydrofuran
4: TFA / CH2Cl2
5: BOP; DIEA / dimethylformamide
With
di-isopropyl azodicarboxylate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
3: Mitsunobu reaction;
DOI:10.1021/jm010127e
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C
1.2: 64 percent / aq. H2O2; AcONa / tetrahydrofuran / 0.33 h / 0 °C
2.1: H2 / Pd/C / methanol / 3 h
3.1: 90 percent / BOP; DIEA / dimethylformamide
4.1: 55 percent / DIAD; PPh3 / tetrahydrofuran
5.1: TFA / CH2Cl2
6.1: BOP; DIEA / dimethylformamide
With
9-borabicyclo[3.3.1]nonane dimer; di-isopropyl azodicarboxylate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
4.1: Mitsunobu reaction;
DOI:10.1021/jm010127e
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 62 percent / DBU / benzene / 4 h / Heating
2.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C
2.2: 64 percent / aq. H2O2; AcONa / tetrahydrofuran / 0.33 h / 0 °C
3.1: H2 / Pd/C / methanol / 3 h
4.1: 90 percent / BOP; DIEA / dimethylformamide
5.1: 55 percent / DIAD; PPh3 / tetrahydrofuran
6.1: TFA / CH2Cl2
7.1: BOP; DIEA / dimethylformamide
With
9-borabicyclo[3.3.1]nonane dimer; di-isopropyl azodicarboxylate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
5.1: Mitsunobu reaction;
DOI:10.1021/jm010127e
