7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal

Base Information

• Chemical Name: 7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal
• CAS No.: 57963-30-1
• Molecular Formula: C₂₂H₂₅ClN₄O₂
• Molecular Weight: 412.919

Synonyms:7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal

Chemical Property of 7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal

Chemical Property:

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Technology Process of 7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal

There total 5 articles about 7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-azidomethyl-[1,3]dioxolan-2-ylmethyl)-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)-amine (57963-28-7) → 7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal (57963-30-1)

Guidance literature:

With formaldehyd; hydrogen; sodium cyanoborohydride; acetic acid; In palladium on charcoal catalyst; ethyl acetate; acetonitrile;

Reference yield:

N-<<2-<(dimethylamino)methyl>-1,3-dioxolan-2-yl>methyl>phthalimide (57963-15-2) → 7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal (57963-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 18 h / Ambient temperature

2: butan-1-ol / 0.5 h / 60 °C

With hydrazine hydrate; In ethanol; butan-1-ol;

DOI:10.1021/jo00321a010

Reference yield:

C-(2-Dimethylaminomethyl-[1,3]dioxolan-2-yl)-methylamine (76879-44-2) + 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione (4547-02-8) → 7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal (57963-30-1)

Guidance literature:

In butan-1-ol; at 60 ℃; for 0.5h;

DOI:10.1021/jo00321a010

upstream raw materials:

C-(2-Dimethylaminomethyl-[1,3]dioxolan-2-yl)-methylamine

7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione

N-<<2-<(dimethylamino)methyl>-1,3-dioxolan-2-yl>methyl>phthalimide

(2-azidomethyl-[1,3]dioxolan-2-ylmethyl)-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)-amine

Downstream raw materials:

8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine

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