8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine

Base Information

• Chemical Name: 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine
• CAS No.: 57963-20-9
• Molecular Formula: C₂₀H₁₉ClN₄
• Molecular Weight: 350.851

Synonyms:8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine

Chemical Property of 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine

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Technology Process of 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine

There total 4 articles about 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-methylamine (76879-36-2) → 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine (57963-20-9)

Guidance literature:

With sodium cyanoborohydride; In acetonitrile; for 2h; pH 6.4-6.8;

DOI:10.1021/jo00321a010

Reference yield: 20.0%

N,N-dimethyl(methylene)ammonium chloride (30354-18-8) + (1,2-a)4H-imidazo (1,4)benzodiazepine 4 oxide (41282-24-0) → (8-Chloro-6-phenyl-4H-3,5,10b-triaza-benzo[e]azulen-4-ylmethyl)-dimethyl-amine (121899-05-6) + (8-Chloro-4-dimethylaminomethyl-6-phenyl-4H-3,5,10b-triaza-benzo[e]azulen-1-ylmethyl)-dimethyl-amine (121899-06-7) + 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine (57963-20-9)

Guidance literature:

In N,N-dimethyl-formamide; at 55 - 59 ℃; for 72h;

Reference yield:

7-chloro-5-phenyl-2-[[3-(dimethylamino)acetonyl]amino]-3H-1,4-benzodiazepine, ethylene ketal (57963-30-1) → 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo]1,2-a][1,4]benzodiazepine + 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine (57963-20-9)

Guidance literature:

In diethylene glycol;

upstream raw materials:

formaldehyd

C-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-methylamine

N,N-dimethyl(methylene)ammonium chloride

(1,2-a)4H-imidazo (1,4)benzodiazepine 4 oxide

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