9-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

Base Information

• Chemical Name: 9-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one
• CAS No.: 81593-58-0
• Molecular Formula: C₁₈H₁₉NO₄S
• Molecular Weight: 345.419
• Mol file: 81593-58-0.mol

Synonyms:9-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

Chemical Property of 9-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

Chemical Property:

Purity/Quality:

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Technology Process of 9-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

There total 5 articles about 9-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid (81593-56-8) → 6-methoxy-2-(4-methylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline (64880-95-1) + 7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one (81593-57-9) + 9-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one (81593-58-0)

Guidance literature:

With phosphorus pentoxide; In dichloromethane; at 0 ℃; for 24h; Inert atmosphere;

DOI:10.1002/cmdc.201000005

Reference yield: 26.0%

[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetyl chloride → 7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one (81593-57-9) + 9-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one (81593-58-0)

Guidance literature:

With aluminium trichloride; In dichloromethane; 1.) 5 h, -65 deg C, 2.) 12 h, room temp.;

DOI:10.1248/cpb.30.180

Reference yield: 11.0%

[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid (81593-56-8) → 9-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one (81593-58-0)

Guidance literature:

With phosphorus pentoxide; In dichloromethane; at 0 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b00812

upstream raw materials:

N-[(3-methoxyphenyl)ethyl]-4′′-methylbenzenesulfonamide

[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid