rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester

Base Information

Chemical Name:rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester
CAS No.:1262841-34-8
Molecular Formula:C₁₂H₁₁F₃INO₃
Molecular Weight:401.124
Hs Code.:

Synonyms:rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester

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Chemical Property of rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester

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Technology Process of rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester

There total 2 articles about rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1262841-29-1
methyl 3-(4-iodophenyl)-2-methoxy-2-(2,2,2-trifluoroacetamido)propanoate

: 1262841-34-8
rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 0 - 40 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.10.132

Reference yield:

: 2612-19-3
N-trifluoroacetyl-D/L-phenylalanine methyl ester

: 1262841-34-8
rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester

: 1326706-81-3
rac-2-(2,2,2-trifluoroacetylamino)-3-(2-iodophenyl)propionic acid methyl ester

Guidance literature:: With tetrafluoroboric acid; [bis(pyridine)iodine]⁺ tetrafluoroborate; trifluoroacetic acid; In dichloromethane; at 40 ℃; Darkness;
DOI:10.1016/j.bmc.2011.06.001

Reference yield:

: 107-59-5
tert-Butyl chloroacetate

: 1262841-34-8
rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester

: methyl 3-(4-(2-(tert-butoxy)-2-oxoethyl)phenyl)-2-(2,2,2-trifluoroacetamido)propanoate

Guidance literature:: With nickel(II) bromide dimethoxyethane; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; N-ethyl-N,N-diisopropylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In N,N-dimethyl-formamide; at 20 ℃; Sealed tube; Inert atmosphere; Irradiation;
DOI:10.1021/acs.orglett.1c01200