2612-19-3

Upstream product

• 58137-35-2 methyl 2-(trifluoroacetamido)acrylate 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 
• 15028-44-1 DL-phenylalanine methyl ester 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1326706-82-4 rac-2-(2,2,2-trifluoroacetylamino)-3-(2-isopropenylphenyl)propionic acid methyl ester 
• 1262841-34-8 rac-2-(2,2,2-trifluoroacetylamino)-3-(4-iodophenyl)propionic acid methyl ester 
• 1326706-81-3 rac-2-(2,2,2-trifluoroacetylamino)-3-(2-iodophenyl)propionic acid methyl ester 
• 2563-33-9 N-trifluoroacetyl-L-phenylalanine ethyl ester 

Relevant academic research and scientific papers

Efficient Access to Alanine Derivatives by 1,4-Additions of Potassium Trifluoro(organo)borates

Potassium trifluoro(organo)borates, highly stable and easily prepared organoboran derivatives, were able to react with a great variety of dehydroamino esters. This reaction, catalyzed by rhodium complexes, allowed the formation of alanine derivatives bearing a great variety of amino protecting groups in good to high yields.

Single enantiomer free-radical chemistry - Lewis acid-mediated reductions of racemic halides using chiral non-racemic stannanes

Additions of one to two equivalents of Lewis acids that include magnesium salts to free-radical reduction reactions involving ester functionalized radicals and (1R,2S,5R)-menthyldiphenyltin hydride 4, bis((1R,2S,5R)-menthyl) phenyltin hydride 5, tris((1R,

The enzyme-catalysed stereoselective transesterification of phenylalanine derivatives in supercritical carbon dioxide

The subtilisin Carlsberg catalysed transesterification of N-acetyl phenylalanine methyl ester (1), N-acetyl phenylalanine ethyl ester (2), N-trifluoroacetyl phenylalanine methyl ester (3) and N-trifluoroacetyl phenylalanine ethyl ester (4) was studied in supercritical carbon dioxide. The water content of the reaction affects the reactivity of the system; for the transesterification of the methyl esters with ethanol the optimum concentration of water was determined to be about 0.74 M, while for the transesterification of the ethyl esters with methanol the optimum concentration of water was about 1.3 M. The conversion is also dependent upon the concentration of alcohol; for ethanol, 2% v/v gives the maximum conversion, whilst for methanol, only 0.8-1. 2% v/v is required. This is probably due to a difference in the solubility of the substrates in the two alcohol/supercritical carbon dioxide mixtures. The reaction is highly stereoselective, in all cases no evidence for reaction of the D-isomer could be detected by chiral gas chromatography.