2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-propyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Base Information

Chemical Name:2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-propyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
CAS No.:1450621-62-1
Molecular Formula:C₂₁H₂₄F₆N₄O₃S
Molecular Weight:526.503
Hs Code.:

Synonyms:2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-propyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Property of 2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-propyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Technology Process of 2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-propyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

There total 7 articles about 2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-propyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361224-48-7
2-(4-(4-((6-amino-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1450621-62-1
2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-propyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: With palladium on activated charcoal; hydrogen; for 6h; under 38002.6 Torr;

Reference yield:

: 6684-39-5
2-chloropyridine-5-sulfonyl chloride

: 1450621-62-1
2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-propyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.17 h / 0 °C

2: ammonium hydroxide / ethanol / 6 h / 110 - 120 °C

3: palladium on activated charcoal; hydrogen / 6 h / 38002.6 Torr

With ammonium hydroxide; palladium on activated charcoal; hydrogen; triethylamine; In ethanol; dichloromethane;

Reference yield:

: 1361224-51-2
benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate

: 1450621-62-1
2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-propyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluorormethanesulfonic acid; trifluoroacetic acid / 23 °C

1.2: pH 7

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

3.1: ammonium hydroxide / ethanol / 6 h / 110 - 120 °C

4.1: palladium on activated charcoal; hydrogen / 6 h / 38002.6 Torr

With ammonium hydroxide; trifluorormethanesulfonic acid; palladium on activated charcoal; hydrogen; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;