benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate

Base Information

Chemical Name:benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate
CAS No.:1361224-51-2
Molecular Formula:C₂₄H₂₂F₆N₂O₃
Molecular Weight:500.441
Hs Code.:

Synonyms:benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate

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Chemical Property of benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate

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Technology Process of benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate

There total 6 articles about benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1361224-50-1
benzyl 3-(propan-1-yn-1-yl)piperazine-1-carboxylate

: 2402-72-4
2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1361224-51-2
benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate

Guidance literature:: With chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate; ruphos; In toluene; at 100 ℃; for 1.66667h; Inert atmosphere;
DOI:10.1021/jm4016747

Reference yield:

: 78818-15-2
4-benzyloxycarbonylpiperazin-2-one

: 1361224-51-2
benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dmap / dichloromethane / 1 h / 20 °C

2.1: tetrahydrofuran / 2 h / 0 °C

3.1: trifluoroacetic acid / dichloromethane / -10 - 20 °C

3.2: 2 h

4.1: sodium t-butanolate / ruphos; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct / toluene / 1.5 h / 100 °C / sealed vessel; Inert atmosphere

With triethylamine; trifluoroacetic acid; sodium t-butanolate; dmap; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct; ruphos; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1361224-51-2
benzyl 3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-phenyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / 1,4-dioxane; water / 2.33 h / 20 °C

2.1: triethylamine / dmap / dichloromethane / 1 h / 20 °C

3.1: tetrahydrofuran / 2 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / -10 - 20 °C

4.2: 2 h

5.1: sodium t-butanolate / ruphos; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct / toluene / 1.5 h / 100 °C / sealed vessel; Inert atmosphere

With sodium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; dmap; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;