17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5⁽¹⁰⁾,16-tetraene

Base Information

Chemical Name:17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5⁽¹⁰⁾,16-tetraene
CAS No.:533925-73-4
Molecular Formula:C₂₉H₃₆O₂
Molecular Weight:416.604
Hs Code.:

17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5<sup>(10)</sup>,16-tetraene

Synonyms:17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5⁽¹⁰⁾,16-tetraene

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Chemical Property of 17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5⁽¹⁰⁾,16-tetraene

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Technology Process of 17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5⁽¹⁰⁾,16-tetraene

There total 4 articles about 17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5⁽¹⁰⁾,16-tetraene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-85-1
ethene

: 213337-06-5
(8R,9S,13S,14S)-3-Benzyloxy-13-methyl-17-vinyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthrene

: 533925-73-4
17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5⁽¹⁰⁾,16-tetraene

Guidance literature:: ethene; (8R,9S,13S,14S)-3-Benzyloxy-13-methyl-17-vinyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthrene; With bi(allylnickel bromide); sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; N,N-bis-[(S)-1-phenylethyl]dibenzo[d,f][1,3,2]dioxaphosphepin-6-amine; In dichloromethane; at 0 - 10 ℃; for 2h; under 760.051 Torr; Inert atmosphere;

With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 0 - 20 ℃; for 4.5h;

With potassium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;
DOI:10.1021/ja711475f

Reference yield:

: 9-[(S)-3-((8R,9S,13S,14S)-3-Benzyloxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-butyl]-9-bora-bicyclo[3.3.1]nonane

: 533925-73-4
17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5⁽¹⁰⁾,16-tetraene

Guidance literature:: With potassium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 0.5h;
DOI:10.1021/ol030031+

Reference yield:

: 213337-06-5
(8R,9S,13S,14S)-3-Benzyloxy-13-methyl-17-vinyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthrene

: 533925-73-4
17-(3-hydroxy-1-methylpropyl)-3-(phenylmethoxy)-estra-1,3,5⁽¹⁰⁾,16-tetraene

Guidance literature:: Multi-step reaction with 3 steps

1.1: {[P(cyclohexyl)3]2RuCl(CO)H}; HBF₄*OEt₂ / benzene; diethyl ether / 0.25 h / 20 °C

1.2: 88 percent / benzene; diethyl ether / 7 h / 75 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: 0.30 g / H₂O₂; KOH / H₂O; tetrahydrofuran / 0.5 h / 20 °C

With tetrafluoroboric acid diethyl ether; potassium hydroxide; Ru(CO)H(Cl)(tri(cyclohexyl)phosphine)₃; dihydrogen peroxide; In tetrahydrofuran; diethyl ether; water; benzene;
DOI:10.1021/ol030031+