5α,13α-dihydroxy-7β,9α,10β-triacetoxy-4(20),11(12)-taxadiene

Base Information

• Chemical Name: 5α,13α-dihydroxy-7β,9α,10β-triacetoxy-4(20),11(12)-taxadiene
• CAS No.: 119777-85-4
• Molecular Formula: C₂₆H₃₈O₈
• Molecular Weight: 478.583
• Mol file: 119777-85-4.mol

Synonyms:5α,13α-dihydroxy-7β,9α,10β-triacetoxy-4(20),11(12)-taxadiene

Chemical Property of 5α,13α-dihydroxy-7β,9α,10β-triacetoxy-4(20),11(12)-taxadiene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5α,13α-dihydroxy-7β,9α,10β-triacetoxy-4(20),11(12)-taxadiene

There total 3 articles about 5α,13α-dihydroxy-7β,9α,10β-triacetoxy-4(20),11(12)-taxadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

desacetyl-2' austrospicatine (119777-78-5) → hydroxy-2' dimethylamino-3' phenyl-3' propionate de methyle (119777-75-2) + 5α,13α-dihydroxy-7β,9α,10β-triacetoxy-4(20),11(12)-taxadiene (119777-85-4)

Guidance literature:

With sodium methylate; In methanol; at 0 ℃; for 4h;

Reference yield:

austrospicatine (119777-76-3) → 5α,13α-dihydroxy-7β,9α,10β-triacetoxy-4(20),11(12)-taxadiene (119777-85-4) + bis-desacetyl-2', 13 austrospicatine (119777-77-4) + desacetyl-2' austrospicatine (119777-78-5)

Guidance literature:

With sodium methylate; In methanol; at 0 ℃; for 4h;

Reference yield:

acetic anhydride (108-24-7) + 5α,7β,9α,10β,13α-pentahydroxy-4(20),11(12)-taxadiene (27854-03-1) → 5α,13α-dihydroxy-7β,9α,10β-triacetoxy-4(20),11(12)-taxadiene (119777-85-4) + 5α,7β,9α,10β,13α-pentaacetoxy-4(20),11(12)-taxadiene (27854-02-0) + acetic acid 7,10,13-triacetoxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0(3,8)]pentadec-11-en-9-ylester (87193-98-4)

Guidance literature:

With triethylamine; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1016/S0040-4020(99)00290-2

upstream raw materials:

desacetyl-2' austrospicatine

austrospicatine

acetic anhydride

5α,7β,9α,10β,13α-pentahydroxy-4(20),11(12)-taxadiene

Downstream raw materials:

2-(2,4-dimethoxy-phenyl)-4-isobutyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-[7,9,10-triacetoxy-8,12,15,15-tetramethyl-4-methylene-5-(3-phenyl-acryloyloxy)-tricyclo[9.3.1.0^3,8]pentadec-11-en-13-yl] ester

2-(2,4-dimethoxy-phenyl)-4-isobutyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-(7,9,10-triacetoxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0^3,8]pentadec-11-en-13-yl) ester

C₇₁H₁₀₄O₂₀Si₂