27854-02-0Relevant academic research and scientific papers
Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers
Appendino, Giovanni,Belloro, Emanuela,Jakupovic, Sven,Danieli, Bruno,Jakupovic, Jasmin,Bombardelli, Ezio
, p. 6567 - 6576 (1999)
Starting from taxanes available in multigram amounts from widespread ornamental yews (10-deacetylbaccatin III (4) and 2'-deacetoxyaustrospicatine (5)), two dimeric taxoids (3a, 3b) with potential dual target specificity (β-tubulin and P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.
