2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexyliden)-1-[3-(1H-indol-3-yl)-pyrrolidin-1-yl]-ethanon

Base Information

Chemical Name:2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexyliden)-1-[3-(1H-indol-3-yl)-pyrrolidin-1-yl]-ethanon
CAS No.:695214-65-4
Molecular Formula:C₂₈H₃₂FN₃O
Molecular Weight:445.58
Hs Code.:

Synonyms:2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexyliden)-1-[3-(1H-indol-3-yl)-pyrrolidin-1-yl]-ethanon

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Chemical Property of 2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexyliden)-1-[3-(1H-indol-3-yl)-pyrrolidin-1-yl]-ethanon

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Technology Process of 2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexyliden)-1-[3-(1H-indol-3-yl)-pyrrolidin-1-yl]-ethanon

There total 3 articles about 2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexyliden)-1-[3-(1H-indol-3-yl)-pyrrolidin-1-yl]-ethanon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 870121-96-3
[4-dimethylamino-4-(4-fluorophenyl)-cyclohexylidene]-acetic acid

: 3766-02-7
3-(pyrrolidin-3-yl)-1H-indole

: 695214-65-4
2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexyliden)-1-[3-(1H-indol-3-yl)-pyrrolidin-1-yl]-ethanon

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 120h;

Reference yield:

: 120-72-9
indole

: 695214-65-4
2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexyliden)-1-[3-(1H-indol-3-yl)-pyrrolidin-1-yl]-ethanon

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 36 h / Heating / reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 33.25 h / 0 - 20 °C / Heating / reflux

2.2: 0.33 h

3.1: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / DMF (N,N-dimethyl-formamide) / 120 h / 0 - 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);

Reference yield:

: 10185-29-2
3-(1H-indole-3-yl)pyrrolidine-2,5-dione

: 695214-65-4
2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexyliden)-1-[3-(1H-indol-3-yl)-pyrrolidin-1-yl]-ethanon

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 33.25 h / 0 - 20 °C / Heating / reflux

1.2: 0.33 h

2.1: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / DMF (N,N-dimethyl-formamide) / 120 h / 0 - 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);