(S)-N-((R)-1-(3-hydroxy-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Base Information

Chemical Name:(S)-N-((R)-1-(3-hydroxy-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide
CAS No.:1453070-04-6
Molecular Formula:C₁₄H₂₀F₃NO₂S
Molecular Weight:323.38
Hs Code.:

Synonyms:(S)-N-((R)-1-(3-hydroxy-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((R)-1-(3-hydroxy-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Chemical Property:

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Technology Process of (S)-N-((R)-1-(3-hydroxy-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

There total 8 articles about (S)-N-((R)-1-(3-hydroxy-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453070-03-5
(S)-N,2-dimethyl-N-((R)-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenyl)ethyl)propane-2-sulfinamide

: 1453070-04-6
(S)-N-((R)-1-(3-hydroxy-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1453070-04-6
(S)-N-((R)-1-(3-hydroxy-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

4.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

5.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

6.2: 1 h / -60 - 20 °C

7.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 5 h / 80 °C / Inert atmosphere

8.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 2 h / 0 - 20 °C

With titanium(IV) isopropylate; bis-triphenylphosphine-palladium(II) chloride; oxalyl dichloride; dihydrogen peroxide; diisobutylaluminium hydride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 880652-44-8
3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide

: 1453070-04-6
(S)-N-((R)-1-(3-hydroxy-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

3.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

4.2: 1 h / -60 - 20 °C

5.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 5 h / 80 °C / Inert atmosphere

6.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 2 h / 0 - 20 °C

With titanium(IV) isopropylate; bis-triphenylphosphine-palladium(II) chloride; dihydrogen peroxide; diisobutylaluminium hydride; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; toluene;