(2E)-2-cyano-3-[5-(dimethylamino)furan-2-yl]-N-(3,4-dimethylphenyl)prop-2-enamide

Base Information

• Chemical Name: (2E)-2-cyano-3-[5-(dimethylamino)furan-2-yl]-N-(3,4-dimethylphenyl)prop-2-enamide
• CAS No.: 5933-68-6
• Molecular Formula: C18H19N3O2
• Molecular Weight: 309.3624
• Mol file: 5933-68-6.mol

Synonyms:4-Isopropyl-[1,2,5]thiadiazol-3-ol;3-isopropyl-4-hydroxy-1,2,5-thiadiazole;3-Isopropyl-4-hydroxy-1,2,5-thiadiazol;3-Hydroxy-4-isopropyl-1,2,5-thiadiazol;

Chemical Property of (2E)-2-cyano-3-[5-(dimethylamino)furan-2-yl]-N-(3,4-dimethylphenyl)prop-2-enamide

Chemical Property:

• Vapor Pressure: 1.29E-11mmHg at 25°C
• Melting Point: 84 - 86 °C
• Boiling Point: 537.3°C at 760 mmHg
• Flash Point: 278.7°C
• PSA: 74.25000
• Density: 1.216g/cm³
• LogP: 1.36710

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-2-cyano-3-[5-(dimethylamino)furan-2-yl]-N-(3,4-dimethylphenyl)prop-2-enamide

There total 3 articles about (2E)-2-cyano-3-[5-(dimethylamino)furan-2-yl]-N-(3,4-dimethylphenyl)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-valinamide (4540-60-7,20108-78-5) → 3-Hydroxy-4-isopropyl-1,2,5-thiadiazol (5933-68-6)

Guidance literature:

With disulfur dichloride; In N,N-dimethyl-formamide; for 6h; Inert atmosphere;

Reference yield:

valine amide (13474-14-1) → 3-Hydroxy-4-isopropyl-1,2,5-thiadiazol (5933-68-6)

Guidance literature:

With disulfur dichloride; In N,N-dimethyl-formamide;

DOI:10.1021/jo01284a040

Reference yield:

→ 3-Hydroxy-4-isopropyl-1,2,5-thiadiazol (5933-68-6)

Guidance literature:

2-Amino-3-methyl-buttersaeure-amid, Thionyl-anilin;

DOI:10.1021/jo01344a502

upstream raw materials:

valine amide

L-valinamide