2-Amino-3-methylbutanamide

Base Information

• Chemical Name: 2-Amino-3-methylbutanamide
• CAS No.: 13474-14-1
• Molecular Formula: C₅H₁₂N₂O
• Molecular Weight: 116.163
• European Community (EC) Number: 402-840-7
• DSSTox Substance ID: DTXSID50901018
• Mol file: 13474-14-1.mol

Synonyms:2-amino-3-methylbutanamide;13474-14-1;20108-78-5;d,l- Valinamid;NoName_66;2-amino-3-methyl-butanamide;SCHEMBL247524;SCHEMBL8663459;2-amino-3-methylbutyrimidic acid;DTXSID50901018;MFCD09941740;AKOS000182790;AKOS016051308;SB47675;SB47827;BB 0258505;FT-0704336;EN300-145659

Chemical Property of 2-Amino-3-methylbutanamide

Chemical Property:

• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 116.094963011
• Heavy Atom Count: 8
• Complexity: 90.4

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(=O)N)N

Technology Process of 2-Amino-3-methylbutanamide

There total 12 articles about 2-Amino-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-amino-3-methylbutyronitrile (4475-96-1) → valinamide (13474-14-1,20108-78-5)

Guidance literature:

With formaldehyd; sodium hydroxide; In water; at 20 ℃;

DOI:10.1039/c6cc07530d

Reference yield: 50.0%

→ valinamide (13474-14-1,20108-78-5)

Guidance literature:

Reference yield: 37.0%

t-Boc-L-valine (13734-41-3) → 3-methyl-1,2-diaminobutane (44520-52-7) + tert-butyl alcohol (75-65-0) + valinamide (13474-14-1,20108-78-5)

Guidance literature:

t-Boc-L-valine; With cyclopentyl methyl ether; ammonia; at 200 ℃; under 4500.45 Torr; Sealed tube; Green chemistry;

With cyclopentyl methyl ether; ammonia; hydrogen; at 200 ℃; for 6.5h; under 42004.2 Torr; Cooling with ice; Green chemistry;

DOI:10.1039/d0gc01441a

upstream raw materials:

ethyl 2-bromoisovalerate

4-isopropyl-2,5-oxazolidinedione

valine ethyl ester

hydrogen cyanide

Downstream raw materials:

3-Hydroxy-4-isopropyl-1,2,5-thiadiazol

2-(3,5-difluorophenyl)-5-isopropyl-2-methylimidazolidin-4-one

N-benzylidene-DL-valine amide

N-benzoyl-valine amide