(3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-isoxazolidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: (3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-isoxazolidine-3-carboxylic acid ethyl ester
• CAS No.: 185522-68-3
• Molecular Formula: C₃₂H₄₀N₂O₈S
• Molecular Weight: 612.744

Synonyms:(3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-isoxazolidine-3-carboxylic acid ethyl ester

Chemical Property of (3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-isoxazolidine-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of (3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-isoxazolidine-3-carboxylic acid ethyl ester

There total 3 articles about (3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-isoxazolidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(p-methoxyphenyl)methanone (90-96-0) → (3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-isoxazolidine-3-carboxylic acid ethyl ester (185522-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1: NH₂OH*HCl / ethanol / 3 h / 80 °C

2: borane-pyridine complex, HCl / ethanol / -5 °C

3: benzene / 0.5 h / Heating

4: 82 percent / toluene / 36 h / 25 °C

With hydrogenchloride; borane pyridine; hydroxylamine hydrochloride; In ethanol; toluene; benzene;

DOI:10.1016/0957-4166(96)00407-7

Reference yield:

4,4'-dimethoxybenzophenone oxime (54150-63-9) → (3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-isoxazolidine-3-carboxylic acid ethyl ester (185522-68-3)

Guidance literature:

Multi-step reaction with 3 steps

1: borane-pyridine complex, HCl / ethanol / -5 °C

2: benzene / 0.5 h / Heating

3: 82 percent / toluene / 36 h / 25 °C

With hydrogenchloride; borane pyridine; In ethanol; toluene; benzene;

DOI:10.1016/0957-4166(96)00407-7

Reference yield:

N-[Bis-(4-methoxy-phenyl)-methyl]-hydroxylamine (137389-40-3) → (3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-isoxazolidine-3-carboxylic acid ethyl ester (185522-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 0.5 h / Heating

2: 82 percent / toluene / 36 h / 25 °C

In toluene; benzene;

DOI:10.1016/0957-4166(96)00407-7

upstream raw materials:

bis(p-methoxyphenyl)methanone

4,4'-dimethoxybenzophenone oxime

N-[Bis-(4-methoxy-phenyl)-methyl]-hydroxylamine

Downstream raw materials:

(3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-isoxazolidine-3,5-dicarboxylic acid 5-tert-butyl ester 3-ethyl ester

(3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-isoxazolidine-3,5-dicarboxylic acid 3-ethyl ester

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