(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde

Base Information

Chemical Name:(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde
CAS No.:1369768-90-0
Molecular Formula:C₁₉H₂₁FN₂O₄
Molecular Weight:360.385
Hs Code.:

Synonyms:(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde

Suppliers and Price of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde

There total 11 articles about (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369768-87-5
{(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol

: 1369768-90-0
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde

Guidance literature:: {(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 2h;

Reference yield:

: 1369768-84-2
(1S,5R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]-3-oxabicyclo[3.1.0]hexan-2-one

: 1369768-90-0
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium borohydride / tetrahydrofuran; methanol / 15 h / -30 - 35 °C

2.1: Lipase acrylic resin from Candida Antarctica / tetrahydrofuran / 15 h / 10 - 35 °C / Enzymatic reaction

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 14.5 h / 35 °C / Cooling with ice

4.1: sodium hydroxide; water / ethanol / 2 h / 10 - 35 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

5.2: 2 h / -78 - 0 °C

With lithium borohydride; oxalyl dichloride; di-isopropyl azodicarboxylate; water; dimethyl sulfoxide; triphenylphosphine; sodium hydroxide; Lipase acrylic resin from Candida Antarctica; In tetrahydrofuran; methanol; ethanol; dichloromethane; 3.1: Mitsunobu reaction / 5.1: Swern Oxidation;

Reference yield:

: 1369768-83-1
2-[3-fluoro-4-(methoxymethoxy)phenyl]acetonitrile

: 1369768-90-0
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -15 °C

1.2: -15 - 35 °C

2.1: lithium borohydride / tetrahydrofuran; methanol / 15 h / -30 - 35 °C

3.1: Lipase acrylic resin from Candida Antarctica / tetrahydrofuran / 15 h / 10 - 35 °C / Enzymatic reaction

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 14.5 h / 35 °C / Cooling with ice

5.1: sodium hydroxide; water / ethanol / 2 h / 10 - 35 °C

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

6.2: 2 h / -78 - 0 °C

With lithium borohydride; oxalyl dichloride; di-isopropyl azodicarboxylate; water; sodium hexamethyldisilazane; dimethyl sulfoxide; triphenylphosphine; sodium hydroxide; Lipase acrylic resin from Candida Antarctica; In tetrahydrofuran; methanol; ethanol; dichloromethane; 4.1: Mitsunobu reaction / 6.1: Swern Oxidation;