{(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol

Base Information

Chemical Name:{(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol
CAS No.:1369768-87-5
Molecular Formula:C₁₉H₂₃FN₂O₄
Molecular Weight:362.401
Hs Code.:

Synonyms:{(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol

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Chemical Property of {(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol

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Technology Process of {(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol

There total 11 articles about {(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₅FN₂O₅

: 1369768-87-5
{(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol

Guidance literature:: With water; sodium hydroxide; In ethanol; at 10 - 35 ℃; for 2h;

Reference yield:

: 1369768-85-3
(1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol

: 1369768-87-5
{(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol

Guidance literature:: Multi-step reaction with 3 steps

1: Lipase acrylic resin from Candida Antarctica / tetrahydrofuran / 15 h / 10 - 35 °C / Enzymatic reaction

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 14.5 h / 35 °C / Cooling with ice

3: sodium hydroxide; water / ethanol / 2 h / 10 - 35 °C

With di-isopropyl azodicarboxylate; water; triphenylphosphine; sodium hydroxide; Lipase acrylic resin from Candida Antarctica; In tetrahydrofuran; ethanol; 2: Mitsunobu reaction;

Reference yield:

: 1369768-84-2
(1S,5R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]-3-oxabicyclo[3.1.0]hexan-2-one

: 1369768-87-5
{(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran; methanol / 15 h / -30 - 35 °C

2: Lipase acrylic resin from Candida Antarctica / tetrahydrofuran / 15 h / 10 - 35 °C / Enzymatic reaction

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 14.5 h / 35 °C / Cooling with ice

4: sodium hydroxide; water / ethanol / 2 h / 10 - 35 °C

With lithium borohydride; di-isopropyl azodicarboxylate; water; triphenylphosphine; sodium hydroxide; Lipase acrylic resin from Candida Antarctica; In tetrahydrofuran; methanol; ethanol; 3: Mitsunobu reaction;