2',5'-Dichloroacetanilide

Base Information

• Chemical Name: 2',5'-Dichloroacetanilide
• CAS No.: 2621-62-7
• Molecular Formula: C8H7 Cl2 N O
• Molecular Weight: 204.056
• Hs Code.: 2924299090
• European Community (EC) Number: 220-062-4
• NSC Number: 28454
• DSSTox Substance ID: DTXSID9062560
• Nikkaji Number: J37.713I
• Wikidata: Q81990109
• Mol file: 2621-62-7.mol

Synonyms:2',5'-Dichloroacetanilide;2621-62-7;N-(2,5-Dichlorophenyl)acetamide;2,5-Dichloroacetanilide;Acetamide, N-(2,5-dichlorophenyl)-;2,5-Dichloracetanilid;ACETANILIDE, 2',5'-DICHLORO-;2,5-Dichloracetanilid [Czech];2-(2,5-Dichlorophenyl)acetamide;EINECS 220-062-4;NSC 28454;BRN 2096825;AI3-17600;4-12-00-01251 (Beilstein Handbook Reference);Acetanilide,5'-dichloro-;SCHEMBL2388970;DTXSID9062560;ICZFWTSENFTULW-UHFFFAOYSA-;HMS1762O01;CAA62162;NSC28454;N-(2,5-dichloro-phenyl)-acetamide;N-(2,5-Dichlorophenyl)acetamide #;AB6993;MFCD00018519;NSC-28454;STK416572;AKOS001044971;AS-61796;CS-0314998;D0307;FT-0634404;Z28136791

Chemical Property of 2',5'-Dichloroacetanilide

Chemical Property:

• Melting Point: 135 °C
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 346.2°Cat760mmHg
• Flash Point: 163.2°C
• PSA: 29.10000
• Density: 1.393g/cm³
• LogP: 3.02480
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 202.9904692
• Heavy Atom Count: 12
• Complexity: 174

Purity/Quality:

97% ^*data from raw suppliers

2',5'-Dichloroacetanilide >98.0%(N) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=CC(=C1)Cl)Cl

Technology Process of 2',5'-Dichloroacetanilide

There total 10 articles about 2',5'-Dichloroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,5 dichloroaniline (95-82-9) + acetic anhydride (108-24-7) → 2,5-dichloroacetanilide (2621-62-7)

Guidance literature:

With supported L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate on Silica Gel; at 20 ℃; for 1.2h; Green chemistry;

DOI:10.2174/1570178611310050004

Reference yield: 78.0%

3-Chloroacetanilide (588-07-8) → 2,5-dichloroacetanilide (2621-62-7)

Guidance literature:

With N-chloro-succinimide; methanesulfonic acid; nickel(II) chloride hexahydrate; In water; at 20 ℃; for 5h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Sealed tube; Microwave irradiation; Green chemistry;

DOI:10.1055/s-0040-1705972

Reference yield: 70.0%

3-Chloroacetanilide (588-07-8) → 2,5-dichloroacetanilide (2621-62-7) + N-(3,4-dichlorophenyl)acetamide (2150-93-8)

Guidance literature:

With N-chloro-succinimide; acetic acid; palladium diacetate; at 100 ℃; for 12h;

DOI:10.1016/j.tet.2006.06.075

upstream raw materials:

2,5 dichloroaniline

acetic anhydride

N-chloro-m-chloroacetanilide

acetic acid

Downstream raw materials:

2,5-dichlorophenylisocyanate

2,5-bis(phenylthio)acetanilide

3,6-dichloro-2-nitro-aniline

N⁴-Acetyl-2.5-dichlor-sulfanilylhydrazid