Technology Process of 2,3,6-tri-O-benzyl-glucose crown ether
There total 13 articles about 2,3,6-tri-O-benzyl-glucose crown ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,3,6-tri-O-benzyl-4-O-(tetraethylene glycolyl)-phenyl-β-D-glucopyranoside;
With
ammonium hexafluorophosphate;
In
acetonitrile;
at 20 ℃;
for 1h;
With
iron(III) chloride;
at 40 ℃;
for 48h;
DOI:10.1039/d1cc00878a
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 91 percent / NaH / tetrahydrofuran / 24 h / Heating
2: 80 percent / NaCNBH3, HCl / diethyl ether; tetrahydrofuran / 0.17 h / Ambient temperature
3: NaH / tetrahydrofuran / 0.5 h / 70 °C
4: 1) O3, 2) NaBH4 / 1) MeOH, -78 deg C, 2) -78 deg C -> room temperature, 12 h
5: 33 percent / NaH / tetrahydrofuran / 24 h / 70 °C
With
hydrogenchloride; sodium tetrahydroborate; sodium hydride; sodium cyanoborohydride; ozone;
In
tetrahydrofuran; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 69 percent / dimethyl sulfate / dimethylformamide / 18 h / Ambient temperature
2: 91 percent / NaH / tetrahydrofuran / 24 h / Heating
3: 80 percent / NaCNBH3, HCl / diethyl ether; tetrahydrofuran / 0.17 h / Ambient temperature
4: NaH / tetrahydrofuran / 0.5 h / 70 °C
5: 1) O3, 2) NaBH4 / 1) MeOH, -78 deg C, 2) -78 deg C -> room temperature, 12 h
6: 33 percent / NaH / tetrahydrofuran / 24 h / 70 °C
With
hydrogenchloride; sodium tetrahydroborate; sodium hydride; sodium cyanoborohydride; ozone; dimethyl sulfate;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
