Erythrosin(E)

Base Information

Chemical Name:Erythrosin(E)
CAS No.:548-25-4
Molecular Formula:C20H8I4O5
Molecular Weight:835.899
Hs Code.:
NSC Number:4905
DSSTox Substance ID:DTXSID60203272
Nikkaji Number:J24.818E
Wikidata:Q27164028
ChEMBL ID:CHEMBL1160028

Synonyms:Erythrosin(E);548-25-4;2,4,5,7-Tetraiodofluorescein;TETRAIDOFLUORESCEIN;2-(6-Hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-9-yl)benzoic acid;2-(3-hydroxy-2,4,5,7-tetraiodo-6-oxoxanthen-9-yl)benzoic acid;NSC 4905;TIF;Benzoic acid, 2-(6-hydroxy-2,4,5,7-tetroiodo-3-oxo-3H-xanthen-9-yl)-;SCHEMBL35487;2,4,5,7-tetraiodfluorescein;CHEMBL1160028;CHEBI:92265;DTXSID60203272;NSC4905;BBL002827;BDBM50541114;MFCD00005044;STK378238;AKOS005448345;VS-01235;A8108;C.I.45430:2;BRD-K14920963-304-01-9;Q27164028;2-(3-hydroxy-2,4,5,7-tetraiodo-6-oxo-9-xanthenyl)benzoic acid;2-(6-Hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-9-yl)benzoic acid #;2-(6-HYDROXY-2,4,5,7-TETRAIODO-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID

Suppliers and Price of Erythrosin(E)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of Erythrosin(E)

Chemical Property:

Vapor Pressure:3.56E-20mmHg at 25°C
Boiling Point:693.2°C at 760 mmHg
Flash Point:373°C
Density:2.83g/cm³
XLogP3:5.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:835.6551
Heavy Atom Count:29
Complexity:848

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)I)O)I)I)I)C(=O)O

Technology Process of Erythrosin(E)

There total 6 articles about Erythrosin(E) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 518-45-6
fluorescein free acid

: 548-25-4
erythrosine B

Guidance literature:: With iodine; iodic acid; In ethanol; water; at 60 ℃;
DOI:10.1016/j.bmc.2010.06.069

Reference yield:

: 518-44-5
dihydrofluorescein

: 548-25-4
erythrosine B

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / pyridine / Ambient temperature

2: 77 percent / DCC, 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / Ambient temperature

3: 29 percent / 1.) NH₃ vapor, 2.) iodine vapor / 1.) 15 min, 2.) 15 min

4: 2N NaOH / methanol / 2 h / Ambient temperature

With dmap; sodium hydroxide; ammonia; iodine; dicyclohexyl-carbodiimide; In pyridine; methanol; dichloromethane;
DOI:10.1002/hlca.19840670136

Reference yield:

: 35340-49-9
dihydrofluorescein diacetate

: 548-25-4
erythrosine B

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / DCC, 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: 29 percent / 1.) NH₃ vapor, 2.) iodine vapor / 1.) 15 min, 2.) 15 min

3: 2N NaOH / methanol / 2 h / Ambient temperature

With dmap; sodium hydroxide; ammonia; iodine; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1002/hlca.19840670136