(3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Base Information

Chemical Name:(3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
CAS No.:1202382-31-7
Molecular Formula:C₄₂H₄₀N₂O₆S
Molecular Weight:700.855
Hs Code.:

(3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Synonyms:(3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Chemical Property of (3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Technology Process of (3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

There total 1 articles about (3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1202382-30-6
(3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-formyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 1779-49-3
Methyltriphenylphosphonium bromide

: 1202382-31-7
(3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: Methyltriphenylphosphonium bromide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 20 ℃; for 0.5h;

(3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-formyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine; In tetrahydrofuran; toluene; for 4h; Reflux;
DOI:10.1021/jo902346j

Reference yield: 32.0%

: 1202382-31-7
(3R,6R,7R,8S,8aR)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 1202382-32-8
C₄₂H₄₀N₂O₆S

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; for 384h; Reflux;
DOI:10.1021/jo902346j