(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate
CAS No.:1208330-70-4
Molecular Formula:C₂₄H₂₄N₂O₄
Molecular Weight:404.466
Hs Code.:

Synonyms:(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

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Chemical Property of (E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

Chemical Property:

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Technology Process of (E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

There total 9 articles about (E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1208330-66-8
4-(3-formyl-1-(4-methoxyphenyl)-1H-pyrrol-2-yl)-3-methylbenzamide

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1208330-70-4
(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

Guidance literature:: In toluene; Reflux;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1208330-62-4
C₂₀H₂₀N₂O₃

: 1208330-70-4
(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 48 h / Reflux

2: toluene / Reflux

With manganese(IV) oxide; In dichloromethane; toluene; 2: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate

: 1208330-70-4
(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: ozone / dichloromethane / 1 h / -78 °C

3.1: pyridinium p-toluenesulfonate / ethanol / 20 °C

4.1: N,N-dimethyl-formamide / 12 h / 180 °C

5.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

6.1: manganese(IV) oxide / dichloromethane / 48 h / Reflux

7.1: toluene / Reflux

With manganese(IV) oxide; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; ozone; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; 7.1: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086