Technology Process of N7-(3,4,5-trimethoxy-phenyl)-[1,5]naphthyridine-2,7-diamine
There total 4 articles about N7-(3,4,5-trimethoxy-phenyl)-[1,5]naphthyridine-2,7-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
toluene;
at 80 ℃;
for 24h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C
2: trichlorophosphate / dichloromethane / 18 h / Reflux
3: ammonia / 1,4-dioxane; water / 24 h / 160 °C / Sealed reactor
4: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 24 h / 80 °C / Inert atmosphere
With
ammonia; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trichlorophosphate / dichloromethane / 18 h / Reflux
2: ammonia / 1,4-dioxane; water / 24 h / 160 °C / Sealed reactor
3: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 24 h / 80 °C / Inert atmosphere
With
ammonia; sodium t-butanolate; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane; dichloromethane; water; toluene;
