17965-71-8

Basic information

• Product Name: 3-Bromo-1,5-naphthyridine
• Synonyms: 3-bromo-1,5-naphthyridine;3-broMo-1;5-naphthyridine;1,5-Naphthyridine,3-bromo-
• CAS NO: 17965-71-8
• Molecular Formula: C₈H₅BrN₂
• Molecular Weight: 209.04
• Product Categories: Heterocycle-Pyridine series
• Mol File: 17965-71-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 289 °C
• Flash Point: 129 °C
• Appearance: /
• Density: 1.656
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.685
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.43±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-1,5-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-1,5-naphthyridine(17965-71-8)
• EPA Substance Registry System: 3-Bromo-1,5-naphthyridine(17965-71-8)

Safety Data

• Hazardous Substances Data: 17965-71-8(Hazardous Substances Data)

Usage

General Description

3-Bromo-1,5-naphthyridine is a chemical compound with the molecular formula C8H5BrN2. It is a halogenated heterocyclic compound that belongs to the naphthyridine family. The presence of the bromine atom in its structure gives it unique chemical and physical properties. 3-Bromo-1,5-naphthyridine is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It has been studied for its potential use in the treatment of various diseases and as an intermediate in the synthesis of biologically active compounds. Additionally, 3-Bromo-1,5-naphthyridine has also been investigated for its antimicrobial and antiviral properties, making it a versatile and important chemical in the field of medicinal chemistry.

InChI:InChI=1/C8H5BrN2/c9-6-4-8-7(11-5-6)2-1-3-10-8/h1-5H

Upstream product

• 28733-43-9 5-bromonicotinamide 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 39620-02-5 5-bromonicotinoyl chloride 
• 13535-01-8 3-amino-5-bromopyridine 
• 56-81-5 glycerol 
• 462-08-8 pyridin-3-ylamine 
• 27305-48-2 1,5-naphthyridine N-⁽¹⁾-oxide 
• 254-79-5 1,5-naphthyridine 

Downstream Products

• 1309774-15-9 1-(7-bromo-1,5-naphthyridin-4-yl)-3-cyclohexylurea 
• 1309774-16-0 1-(7-bromo-1,5-naphthyridin-4-yl)-3-phenylurea 
• 1309774-19-3 1-benzyl-3-(7-bromo-1,5-naphthyridin-4-yl)urea 
• 1309774-26-2 1-(7-bromo-1,5-naphthyridin-4-yl)-3-(2-phenylethyl)urea 
• 1309774-22-8 1-(7-bromo-1,5-naphthyridin-4-yl)-3-(4-phenylbutyl)urea 
• 1309773-68-9 1-[7-(3,4-dimethoxyphenyl)-1,5-naphthyridin-4-yl]-3-ethylurea 
• 1309773-71-4 1-ethyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-4-yl]urea 
• 1309773-80-5 1-[7-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-4-yl]-3-ethylurea 
• 1309773-70-3 1-tert-butyl-3-[7-(3,4-dimethoxyphenyl)-1,5-naphthyridin-4-yl]-urea 
• 1309773-77-0 1-tert-butyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-4-yl]urea 
• 1309773-78-1 1-tert-butyl-3-[7-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-4-yl]urea 
• 1309773-79-2 1-cyclopropyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-4-yl]urea 
• 1309773-88-3 1-cyclohexyl-3-[7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridin-4-yl]urea 
• 1309773-89-4 1-[7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridin-4-yl]-3-phenylurea 

Relevant articles and documents

SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS

The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

ALK5 INHIBITORS

The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.